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Lea Barny on Muck Rack

Lea Barny

As seen in: ACS Publications, BioRxiv, The Journal of Biological Chemistry
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Articles

Development of an Adaptive, Economical, and Easy-to-Use SP3-TMT Automated Sample Preparation Workflow for Quantitative Proteomics

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By Jake N Hermanson, Lea Barny, Lars Plate
Introduction Click to copy section linkSection link copied! Advancements in mass spectrometry (MS) instrumentation has enabled the study of proteins with high sensitivity and reproducibility in both basic and translational research at an unprecedented scale. (1−6) Regardless of the application, reproducible sample preparation is essential for minimizing technical variability to avoid obscuring biological insight.
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Development of an Adaptive, Economical, and Easy-to-Use SP3-TMT Automated Sample Preparation Workflow for Quantitative Proteomics

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By Jake N Hermanson, Lea Barny, Lars Plate
| ACS Publications
Introduction Click to copy section linkSection link copied! Advancements in mass spectrometry (MS) instrumentation has enabled the study of proteins with high sensitivity and reproducibility in both basic and translational research at an unprecedented scale. (1−6) Regardless of the application, reproducible sample preparation is essential for minimizing technical variability to avoid obscuring biological insight.
Open in Who Shared Issue with article?

Dissecting Branch-Specific Unfolded Protein Response Activation in Drug-Tolerant BRAF-Mutant Melanoma using Data-Independent Acquisition Mass Spectrometry

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By Lea Barny, Jake N Hermanson, Sarah Garcia, Philip E Stauffer
| BioRxiv
Abstract Cells rely on the Unfolded Protein Response (UPR) to maintain ER protein homeostasis (proteostasis) when faced with elevated levels of misfolded and aggregated proteins. The UPR is comprised of three main branches-ATF6, IRE1, and PERK-that coordinate the synthesis of proteins involved in folding, trafficking, and degradation of nascent proteins to restore ER function. Dysregulation of the UPR is linked to numerous diseases, including neurodegenerative disorders, cancer, and diabetes.
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