Leah Mayo

Introduction Cannabis and cannabis-based therapeutics, including the main cannabinoids Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), have long been of interest in psychiatry. While there have been promising advances in cannabinoid-based treatments for adults, their use in children and adolescents is limited, in part due to the reported negative impacts on neurodevelopment (Albaugh et al., 2021).

Commentary Open Access | 10.1172/JCI192414 Published in Volume 135, Issue 9 on May 1, 2025 J Clin Invest. 2025;135(9):e192414. https://doi.org/10.1172/JCI192414. © 2025 Petrie,, et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Mehdi Farokhnia, … , Christopher T.

ResearchClinical ResearchNeuroscience Open Access | 10.1172/JCI179881 J Clin Invest. https://doi.org/10.1172/JCI179881. Copyright © 2025, Rosas-Vidal et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract Maladaptive fear generalization is one of the hallmarks of trauma-related disorders.