Lee Adam Wheeler on Muck Rack

Lee Adam Wheeler

As seen in: Cell Press
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Articles

TREX1 Knockdown Induces an Interferon Response to HIV that Delays Viral Infection in Humanized Mice

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By Inflammatory Diseases, Lee Adam Wheeler, Radiana T. Trifonova, Vladimir Vrbanac, Natasha S. Barteneva
| Cell Press Verified
TREX1 Knockdown in CD4+ Cells In Vitro and in Human Cervicovaginal Tissue Explants Exposure of MDMs to Type I IFN Inhibits HIV Replication when Administered Just before or after Infection TREX1 Knockdown IVAG or Topical rIFN Upregulate ISGs and Inhibit Early HIV Replication in Humanized BLT Mice TREX1 CD4-AsiCs Upregulate Gene Expression of Type I IFNs and ISGs in the Vaginal Tissue of HIV-Exposed Humanized BLT Mice TREX1 CD4-AsiCs Delay, but Do Not Prevent, Transmission of HIV to Humanized...
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