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Articles by Lee SJ
Polyphenols and microglial dynamics in neurodegenerative diseases: mechanistic advances and therapeutic perspectives
The target audience is researchers, clinicians, and students in the fields of neuroscience, pharmacology, and medicine, particularly those interested in neuroinflammation, microglial phenotypic balance and polarization states, and the neuroprotective effects of polyphenols. Several pivotal steps were taken to guarantee the comprehensiveness and objectivity of this review.
Discovery of serum APOD as an early sarcopenia biomarker in older adults with low muscle mass: a cross-sectional proteomic and transcriptomic investigation
1Department of Physical Education, Guangxi Medical University, Nanning, Guangxi, China 2School of Physical Education and Health Science, Guangxi Minzu University, Nanning, Guangxi, China 3Sports and Health College, Tianjin Medical University, Tianjin, China DOI 10.7717/peerj.21058 Academic Editor Vladimir Uversky Subject Areas Bioinformatics, Geriatrics, Orthopedics Keywords Sarcopenia, Serum proteomics, Function information, APOD, Diagnostic value Copyright © Licence This is an open access...
A comparative study of dimensionality reduction techniques for intrusion detection in IoT networks
The integration of Internet of Things (IoT) and Artificial Intelligence (AI) technologies has enabled the interconnection of heterogeneous devices, sensors, and services, allowing real-time monitoring, automation, and intelligent decision-making. These capabilities have proven especially valuable in rural areas, where infrastructure is often limited and resources must be managed efficiently, giving rise to the concept of Smart Rural (Nawaz & Babar, 2025).
Prediction of miRNA-disease associations using a dual-channel contrastive model based on multi-source information fusion
MicroRNAs (miRNAs) are a class of endogenous non-coding small RNA molecules about 21–25 nucleotides in length. Through complementary binding to target messenger RNAs (mRNAs), they control gene expression post-transcriptionally, thereby significantly influencing biological functions including cell proliferation, differentiation, apoptosis, and metabolic homeostasis (Calin & Croce, 2006; Bartel, 2009; Jonas & Izaurralde, 2015).
A hybrid CNN-GRU model with XAI-Driven interpretability using LIME and SHAP for static analysis in malware detection
With the rapid advancement of computer technologies, malware has become a significant threat to cybersecurity for individuals, organizations, and even entire nations. Therefore, it is imperative to detect and eliminate malware as soon as possible. Malware analysis is the process of understanding the behavior of malware or malicious code and determining the impact of malware on systems.
Significance of the inflammatory-immune-nutritional (IINS) score on postoperative survival and recurrence in breast cancer patients: a retrospective study
Significance of the inflammatory-immune-nutritional (IINS) score on postoperative survival and recurrence in breast cancer patients: a retrospective study 1Human Reproductive and Genetic Center, Affiliated Hospital of Jiangnan University, Wuxi, China 2Department of Histology and Embryology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China 3Department of Breast Surgery, Affiliated Hospital of Jiangnan University, Wuxi, China DOI 10.7717/peerj.19950 Academic Editor...
A retrospective study on beta-blocker use and outcomes in hematopoietic stem cell transplant patients
Matthew A. Bergens conceived and designed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft. John T. Bokman conceived and designed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft. Ernaya J.
A novel hybrid TCN-TE-ANN model for high-precision solar irradiance prediction
As the global community confronts mounting challenges related to environmental sustainability, resource scarcity, and climate change, renewable energy has emerged as a pivotal solution to address these pressing issues (Owusu & Asumadu-Sarkodie, 2016; Singh, 2023). The consumption of fossil fuels is linked to severe environmental and health consequences, including air pollution, climate change, ecological imbalance, and the prevalence of serious diseases (Alizamir et al., 2023).
Superoxide dismutase activity in tear fluid and blood of patients and mouse model of amyotrophic lateral sclerosis: a pilot study
Superoxide dismutase activity in tear fluid and blood of patients and mouse model of amyotrophic lateral sclerosis: a pilot study 1Helmholtz National Medical Research Center for Eye Diseases of the Ministry of Health of the Russian Federation, Moscow, Russia 2N. V.
Prognostic value of lymphocyte-to-monocyte ratio in patients with endometrial cancer: an updated systematic review and meta-analysis
Precise assessment of metastasis risk at the time of diagnosis and the risk of future recurrence is essential for formulating individualized treatment plans for cancer patients, improving prognosis, and minimizing the side effects of unnecessary adjuvant therapy. In recent years, new methods have emerged to classify EC patients into low-, intermediate-, or high-risk groups.
Metal artifact reduction combined with deep learning image reconstruction algorithm for CT image quality optimization: a phantom study
Huachun Zou performed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft. Zonghuo Wang performed the experiments, prepared figures and/or tables, and approved the final draft. Mengya Guo performed the experiments, analyzed the data, prepared figures and/or tables, and approved the final draft. Kun Peng performed the experiments, prepared figures and/or tables, and approved the final draft.
A comparative analysis of the rhizosphere microbial communities among three species of the Salix genus
A comparative analysis of the rhizosphere microbial communities among three species of the Salix genus 1Key Laboratory of Medicinal Plant and Animal Resources of the Qinghai-Tibetan Plateau in Qinghai Province, Xining, China 2School of Life Science, Qinghai Normal University, Xining, China 3Qinghai Academy of Agriculture and Forestry Sciences, Qinghai University, Xining, China DOI 10.7717/peerj.19182 Academic Editor Liang Wang Subject Areas Biodiversity, Ecology, Microbiology Keywords Salix,...
Microplastic effects on mouse colon in normal and colitis conditions: A literature review
Natalia Zolotova conceived and designed the experiments, performed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft. Dzhuliia Dzhalilova performed the experiments, authored or reviewed drafts of the article, and approved the final draft. Ivan Tsvetkov performed the experiments, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft.
Efficacy of root canal treatment for autotransplanted third molars: a 6-Year cohort study of 167 teeth in southern China
In this 6-year study, we conducted autogenous tooth transplantation in 167 teeth in Southern China with a mean follow-up of 28.5 months. The overall success rate is 97.6%, with four unsuccessful cases. Among the unsuccessful cases, two teeth were removed due to irreversible Grade III tooth mobility, while the remaining two underwent root canal (re)treatment for salvage, resulting in an overall survival rate of 99.4%.
The associations between well-being and Cloninger’s personality dimensions in a Korean community sample
Personality, as defined by Cloninger (2004), is a dynamic psychobiological internal system, comprising temperament and character dimensions. It serves as the mechanism through which individuals shape and adapt to both internal and external changes. Temperament is considered to be a key element as it is connected to reacting to emotional stimuli, variations in the intensity of responses to emotional events, and the length of emotional reactions (Kim-Prieto et al., 2005; Nigg, 2006).
Ferroptosis-related gene transferrin receptor protein 1 expression correlates with the prognosis and tumor immune microenvironment in cervical cancer
Ferroptosis-related gene transferrin receptor protein 1 expression correlates with the prognosis and tumor immune microenvironment in cervical cancer 1Department of Laboratory Medicine, Lianyungang Affiliated Hospital of Nanjing University of Chinese Medicine, Lianyungang, Jiangsu, China 2Lianyungang Maternal and Child Health Hospital, Lianyungang, Jiangsu, China 3Department of Pathology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China DOI...
Construction of a nomogram for predicting catheter-related bladder discomfort in patients with end-stage renal disease after renal transplantation: a retrospective study
The incidence of CRBD in ESRD patients who underwent RT is relatively high, which may hamper the treatment outcome and compliance. In this study, aberrant BMI, anuria and DJ ureteral stent with a diameter of >5Fr were independent risk factors for CRBD, while sufentanil utilization (>100 µg) was associated with decreased incidence of CRBD. Our established nomogram based on these parameters showed a good discrimination in CRBD, presenting good consistency with the clinical experiences.
Investigating molecular markers linked to acute myocardial infarction and cuproptosis: bioinformatics analysis and validation in the AMI mice model
Investigating molecular markers linked to acute myocardial infarction and cuproptosis: bioinformatics analysis and validation in the AMI mice model Ningbo Medical Center Lihuili Hospital, Medical School of Ningbo University, Ningbo, Zhejiang, China DOI 10.7717/peerj.17280 Academic Editor Brittany Lasseigne Subject Areas Bioinformatics, Cardiology, Internal Medicine, Nutrition Keywords AMI, Cuproptosis, Machine learning, WGCNA, Immune infiltration Copyright © Licence This is an open access...
Population dynamics and seasonal migration patterns of Spodoptera exigua in northern China based on 11 years of monitoring data
Population dynamics and seasonal migration patterns of Spodoptera exigua in northern China based on 11 years of monitoring data 1Shenyang Agricultural University, College of Plant Protection, Shenyang, Liaoning, China 2Liaoning Academy of Agricultural Sciences, Institute of Flower, Shenyang, Liaoning, China DOI 10.7717/peerj.17223 Academic Editor Dagmara Żyła Subject Areas Agricultural Science, Ecology, Entomology, Zoology, Population Biology Keywords Spodoptera exigua, Migration trajectory,...
Waterlogging in soil restricts the growth of Gleditsia sinensis seedlings and inhibits the accumulation of lignans and phenolic acids in thorns
The soil matrix used in this study was divided into two distinct treatment groups: control soil and pindstrup soil. The control soil consisted of a blend of garden soil (purchased from the flower market in Guiyang city) and humus soil (purchased from Organic Fertilizer Development Co., Ltd. in Guiyang city) in a 1:1 (v/v) ratio.
A proposed reconstruction method of a 3D animation scene based on a fuzzy long and short-term memory algorithm
One way human beings access external information is through vision, which is screened, integrated, and analyzed through the brain system so that humans understand and feel the world around them. Research on computer vision, which enables machines to extract and analyze information from vision-based data quickly, has received great attention, similar to how humans achieve a reasonable understanding of external environment information.
Prognostic factors and outcomes of invasive pulmonary aspergillosis, a retrospective hospital-based study
Prognostic factors and outcomes of invasive pulmonary aspergillosis, a retrospective hospital-based study 1Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taiwan 2Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan 3Institute of Biomedical Science and Rong-Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung, Taichung, Taiwan 4Division of Allergy, Immunology and Rheumatology,...
MX1 and UBE2L6 are potential metaflammation gene targets in both diabetes and atherosclerosis
MX1 and UBE2L6 are potential metaflammation gene targets in both diabetes and atherosclerosis 1Department of Radiology, Third Medical Center of Chinese PLA General Hospital, Beijing, China 2Laboratory Animal Center, Chinese People’s Liberation Army General Hospital, Beijing, China 3Department of Radiology, Beijing YouAn Hospital, Capital Medical University, Beijing, China 4Department of Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese...
Guideline for Safe Patient Handling and Movement
The updated AORN “Guideline for safe patient handling and movement” provides recommendations on safe patient handling and mobility (SPHM) programs to decrease patient and personnel injuries.
Swarm intelligence-based packet scheduling for future intelligent networks
There are a large number of packet scheduling techniques that work based on traditional factors, such as weight, priority, class, and arrival order. However, there are very few techniques proposed that consider TAOC characteristics. A prominent scheme in this regard has been proposed by Husen et al. (2021) and Rashid & Muhammad (2019) that considers the TAOC characteristics and network node and layer role.
Followership styles scrutinized: temporal consistency and relationships with job attitudes and self-efficacy
In the following, “followership behavior(s)” refer to Kelley’s (1992) definition and conception. This study was preregistered on the Open Science Framework. Our research is in line with the ethical principles of the Declaration of Helsinki and the Psychologists Code of Conduct of the American Psychological Association. Please note that correlational studies are exempt from institutional review in Germany (see also Sonnentag et al., 2022).
From the perspective of rumen microbiome and host metabolome, revealing the effects of feeding strategies on Jersey Cows on the Tibetan Plateau
Niuniu Yuan conceived and designed the experiments, performed the experiments, analyzed the data, prepared figures and/or tables, authored or reviewed drafts of the article, and approved the final draft. Yicui Wang performed the experiments, analyzed the data, prepared figures and/or tables, and approved the final draft. Qihao Pan performed the experiments, prepared figures and/or tables, and approved the final draft.
Intestinal GPDH-1 regulates high glucose diet induced lifespan extension in aged worms
Intestinal GPDH-1 regulates high glucose diet induced lifespan extension in aged worms 1Luoyang Orthopedic Hospital of Henan Province, Henan, China 2Shenzhen Institute of Advanced Technology, Shenzhen, China 3Anhui Medical University, Hefei, China 4Huang He Science and Technology University, Zhengzhou, China 5Nanjing University, Nanjing, China DOI 10.7717/peerj.15845 Academic Editor Gwyn Gould Subject Areas Biochemistry, Cell Biology, Molecular Biology Keywords High glucose diet, Aging,...
Curcumin Chalcone Derivatives Database (CCDD): a Python framework for natural compound derivatives database
Modern drug development involves identifying possible hits and optimizing them to improve selectivity, specificity, activity, and extent of absorption. Once a molecule with all of the necessary qualities has been found, drug development and clinical trials can begin. Computer-aided drug design is used in one or more phases of the drug discovery procedure. The pharmaceutical business invests a significant amount of money in the modern drug discovery process.
The moderating and mediating effects of personality on the association between morningness and well-being
Many studies have investigated the relationship between morningness and personality, and between personality and well-being. However, there is a paucity of research examining the direct relationship between morningness and personality, and their impact on well-being. We used the TCI-RS to study these features, which we consider is the most appropriate personality instrument for this purpose.
EDIL3 is a potential prognostic biomarker that correlates with immune infiltrates in gastric cancer
Discussion GC is one of the most common and lethal cancers in China (Cao et al., 2021). Comprehensive treatment based on surgery is the standard therapy modality used for GC. In recent years, systemic treatment including chemotherapy, targeted therapy, and immunotherapy have made remarkable advances and breakthroughs, but still with limited efficacy. Therefore, identifying reliable diagnostic biomarkers and effective therapeutic targets for GC continues to be a significant research hotspot.
Parvovirus B19 DNA and antibodies in Chinese plasma donors, plasma pools and plasma derivatives
Discussion Because of its special raw resource, the safety of plasma derivatives is always an important and concerning issue (Di Minno et al., 2016). As a potential contaminant of blood transfusion disease, B19V can cause serious complications in some high-risk patients, such as those with hemophilia, potential hematological malignancy, and immunodeficiency. Due to B19V’s pathogenicity and risk of transmission through plasma derivatives, great attention has been focused on it.
Imaging-Based Versus Pathologic Survival Stratifications of Diffuse Glioma According to the 2021 WHO Classification System
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Interstitial Inflammation in the ISN/RPS 2018 Classification of Lupus Nephritis Predicts Renal Outcomes and is Associated With Bcl-2 Expression
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Causal Effect of the 25-Hydroxyvitamin D Concentration on Cerebral Small Vessel Disease: A Mendelian Randomization Study
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A Postmortem Case Study-An Analysis of microRNA Patterns in a Korean Native Male Calf ( Bos taurus coreanae) That Died of Fat Necrosis
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Reduced volume intensity-modulated radiotherapy with simultaneous integrated boost for patients with high-grade glioma: A retrospective observational study - PubMed
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Device Effectiveness for Femoropopliteal Artery Disease Treatment: An Analysis of K-VIS ELLA Registry
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A case of neutrophilic dermatosis of the hands associated with chronic myelomonocytic leukemia presenting as annular papules and plaques
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Additional Clinical Benefit of Agomelatine Treatment for Major Depressive Disorder in Naturalistic Treatment Setting
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Protective effects of Angelica decursiva Franchet & Savatier on allergic responses through enhancement of Nrf2 and suppression of NF-kB/MMP-9 in ovalbumin-exposed mice - PubMed
doi: 10.1016/j.jep.2023.116863. Online ahead of print. Affiliations Affiliations 1 College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, 77 Yong-bong-ro, Buk-gu, Gwangju, 61186, Republic of Korea.
A real-time, personalized sleep intervention using mathematical modelling and wearable devices
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Ten-year treatment outcomes of consolidation hyperthermic intraperitoneal chemotherapy for ovarian cancer (HIPEC-KOV-03R)
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Novel Frizzled-specific antibody-based Wnt mimetics and Wnt superagonists selectively activate WNT/β-catenin signaling in target tissues
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Bioinformatics Analysis of Novel Targets for Treating Cervical Cancer by Immunotherapy Based on Immune Escape
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Factors associated with the development of coronary artery disease in people with HIV
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Systemic Delivery of a STING Agonist-Loaded Positively Charged Liposome Selectively Targets Tumor Immune Microenvironment and Suppresses Tumor Angiogenesis - PubMed
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Re-Irradiation with Intensity-Modulated Radiation Therapy for the Treatment of Recurrent Cervical Cancer in the Pelvis: An Analysis of Outcomes and Toxicity - PubMed
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Dietary Curcumin Attenuates Hepatic Cellular Senescence by Suppressing the MAPK/NF-κB Signaling Pathway in Aged Mice
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Asymptomatic Type 2 Perioperative Myocardial Infarction Detected before Anesthetic Induction in a Patient Undergoing Non-Cardiac Surgery-A Case Report - PubMed
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