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Articles by Lei Dou
Pharmacokinetic Tuning Redirects β-Lapachone From NQO1 Bioactivation to Vimentin-Targeted Oxidation in Cancer
1 Introduction β-lap is an ortho-naphthoquinone natural compound extracted from the lapacho tree (Tabebuia avellanedae) in South America, and exhibits significant therapeutic anti-tumor activity across various cancer cells [1-4]. β-lap is known to be bioactivated by NAD(P)H: quinone oxidoreductase 1 (NQO1) [3, 5, 6], an enzyme that detoxifies most quinones through a two-electron reduction reaction [7].
Frequency domain solution for distributed drive automotive vibration systems considering motor excitation
Abstract Vibrations of distributed drive electric vehicles (DDEVs) are simultaneously influenced by road and motor excitations. Traditional time-domain approaches struggle to quantify the coupled contributions of these two excitation sources in the frequency spectrum. This paper proposes a frequency-domain decoupling analysis method that separates the coupling effects of motor and road excitations.
Economic analysis of complementary medicine: a systematic review
A multi-center study was performed to identify factors predicting the use of complementary and alternative medicine (CAM) in radiotherapy patients, giving patients the information and the support they request. A total of 1013 consecutive patients receiving radiotherapy for malignant diseases were interviewed using a structured questionnaire. Multivariate logistic stepwise backward regression was used to analyze the replies. A total of 59% of patients reported using CAM therapies.
The humanistic and economic burden of COPD patients in China: A Propen
Back to Journals » International Journal of Chronic Obstructive Pulmonary Disease » Volume 20 Authors Dou L , Zheng Y, Feng J, Huang Z, Qin F, Gao M , Li S Received 20 February 2025 Accepted for publication 13 August 2025 Published 27 August 2025 Volume 2025:20 Pages 2993—3004 DOI https://doi.org/10.2147/COPD.S524028 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 4 Editor who approved publication: Dr Fanny Wai San Ko Lei Dou,1– 4 Yu Zheng,5 Junchao...
Predicting the Zinc Content in Rice from Farmland Using Machine Learning Models: Insights from Universal Geochemical Parameters
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Preparation, Structural Characterization, and Biological Activity of Selenated Potato Resistant Starch
Conflict of Interest The authors declare no conflict of interest. References 1, , , , , J. Integr. Agr. 2017, 16, 2924. 2, , , , J Funct Foods 2022, 93, 105094. 3, , , , Food Chem 2024, 440, 138261. 4, , , , , , Food Hydrocolloid 2022, 132, 107828. 5, , , Food Res. Int. 2006, 39, 332. 6, , Food Chem. 2021, 357, 129758. 7, , , Carbohydr. Polym. 2018, 202, 29. 8, , , , , , Starch - Stärke 2022, 74, 2200025. 9, , , , , , J. Funct. Foods 2019, 61, 103492. 10, , , , , J. Food Meas. Charact. 2021, 16, 945.
Belimumab in early systemic lupus erythematosus: A propensity score matching analysis
1 INTRODUCTION Systemic lupus erythematosus (SLE) is a chronic diffuse connective tissue disease with an unknown etiology, characterized by diverse clinical manifestations and involvement of multiple organ systems.
Gene expression profiles of human periodontal ligament cryopreserved with vitrification using cocktail cryoprotective agents
DATA AVAILABILITY STATEMENT The data that support the findings of this study are available from the corresponding author upon reasonable request.
Health-related quality of life and its changes of the Tibetan population in China: based on the 2013 and 2018 National Health Services Surveys
Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways. PUBLIC HEALTH Quality of Life China We used Tibetan resident data from two National Health Service Surveys conducted in 2013 and 2018.
Robust GNSS Positioning Using Unbiased Finite Impulse Response Filter
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessTechnical Note by 1, 2 and 1,* 1 School of National Key Laboratory of Transient Physics, Nanjing University of Science and Technology, Nanjing 210094, China 2 Department of Aeronautical and Aviation Engineering, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China * Author to whom correspondence should be addressed. Remote Sens.
HLF promotes ovarian cancer progression and chemoresistance via regulating Hippo signaling pathway - Cell Death & Disease
Abstract Hepatic leukemia factor (HLF) is aberrantly expressed in human malignancies. However, the role of HLF in the regulation of ovarian cancer (OC) remains unknown. Herein, we reported that HLF expression was upregulated in OC tissues and ovarian cancer stem cells (CSCs). Functional studies have revealed that HLF regulates OC cell stemness, proliferation, and metastasis.
Dental Pulp Stem Cell-Derived Exosomes Regulate Anti-Inflammatory and | IJN
Introduction As one of the main causes of tooth loss in adults, periodontitis is a destructive periodontal inflammatory disease caused by dental plaque, which affects approximately 90% of the world’s population.1 In clinical practice, current treatments for periodontitis are mechanical debridement techniques (removing subgingival biofilm and dental calculus) supplemented with antibiotics and other drugs.2,3 However, autogenous bone is not easy to form, and damaged periodontal tissue cannot be...
Pilot study of baricitinib for active Sjogren’s syndrome
Pilot study of baricitinib for active Sjogren’s syndrome http://orcid.org/0000-0001-6212-2511Wei Bai1,2, Huilan Liu1,2, Lei Dou3, YunJiao Yang1,2, XiaoMei Leng1,2, http://orcid.org/0000-0003-4252-2889Mengtao Li1,2, http://orcid.org/0000-0001-7808-9867Wen Zhang1,2, Yan Zhao1,2, Xiaofeng Zeng1,2 1 Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences & Peking Union Medical College; National Clinical Research Center for Dermatologic and Immunologic Diseases...
Pilot study of baricitinib for active Sjogren’s syndrome
Pilot study of baricitinib for active Sjogren’s syndrome http://orcid.org/0000-0001-6212-2511Wei Bai1,2, Huilan Liu1,2, Lei Dou3, YunJiao Yang1,2, XiaoMei Leng1,2, http://orcid.org/0000-0003-4252-2889Mengtao Li1,2, http://orcid.org/0000-0001-7808-9867Wen Zhang1,2, Yan Zhao1,2, Xiaofeng Zeng1,2 1Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences & Peking Union Medical College; National Clinical Research Center for Dermatologic and Immunologic Diseases...
Adhesive and non-adhesive internal hernia: clinical relevance and multi-detector CT images
Abstract Internal hernia (IH)-related surgical acute abdomen is not well understood because of the rarity of cases and underdiagnosis. This study was performed to further understand the clinicopathological features and multi-detector computed tomography (MDCT) findings of IH in cases confirmed by surgery. In all, 51 patients with a definite diagnosis of IH confirmed during surgical exploration from Feb. 2012 to Feb. 2018 in our hospital were included in this research.
The validity of caries risk assessment in young adults with past caries experience using a screening Cariogram model without saliva tests
Two‐hundred and fifteen Chinese young adults seeking dental care were included in this observational study, with informed consent obtained. All participants were 18–29 years of age and with past caries experience. A caries risk assessment was made at baseline using a full‐blown Cariogram model and a screening Cariogram model without saliva tests; this assessment included bacterial count, saliva secretion and buffer capacity.
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