Yin Tang
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Wnt-presenting materials sustain H3K14-acetylation in human skeletal stem cells for tissue engineering and bone repair
Abstract Engineering functional tissues for transplantation requires insight into epigenetic mechanisms that regulate stem cell fate. We have developed the Wnt-induced osteogenic tissue model (WIOTM), a platform that recapitulates human osteogenesis, and identified acetylation of histone H3 at lysine 14 (H3K14ac) as a critical epigenetic regulator in human skeletal stem cells (hSSCs).
Belted and Ensembled Neural Network for Linear and Nonlinear Sufficient Dimension Reduction
Advanced search Journal of the American Statistical Association Latest Articles Submit an article Journal homepage Full Article Figures & data References Supplemental Citations Metrics Reprints & Permissions Read this article /doi/full/10.1080/01621459.2025.2590775?needAccess=true Accepted author version Abstract We introduce a unified, flexible, and easy-to-implement framework of sufficient dimension reduction that can accommodate both linear and nonlinear dimension reduction, and both the...
A KL-divergence-based test for elliptical distribution
We conduct a KL-divergence-based procedure for testing elliptical distributions. The procedure simultaneously takes into account the two defining properties of an elliptically distributed random vector: independence between length and direction, and uniform distribution of the direction. The test statistic is constructed based on the k nearest neighbours (kNN) method, and two cases are considered where the mean vector and covariance matrix are known and unknown.
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