CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. Supporting Information Filename Description age70021-sup-0001-DataS1.xlsxExcel 2007 spreadsheet , 26.3 KB Data S1. REFERENCES , , , , , et al. (2010) A method and server for predicting damaging missense mutations. Nature Methods, 7(4), 248–249. Available from: https://doi.org/10.1038/nmeth0410-248 , , & (1991) A sensitive immunoassay for von Willebrand factor. Journal of Immunoassay, 12(3), 371–390.