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Lena Friederick Schimke on Muck Rack

Lena Friederick Schimke

As seen in: Nature
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Systems-level transcriptomic analysis reveals synapse-related gene dysregulation in peripheral leukocytes of MDD patients - Scientific Reports

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By Anny Silva Adri, Adriel Leal Nobile, Pedro Marçal Barcelos, Roseane Galdioli Nava, Rodrigo Dalmolin, Rafael Rezende, Haroldo Dutra Dias, Igor Salerno Filgueiras, Otavio Cabral-Marques, Lena Friederick Schimke, Luiz Fernando Onuchic
| Nature Verified
Abstract Major depressive disorder (MDD) involves both central nervous system dysfunction and systemic immune alterations. Using a systems biology approach, we investigated whether peripheral leukocytes exhibit transcriptional changes in genes annotated to synaptic processes, molecular functions typically associated with neurons but also possibly implicated in immune cell biology.
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