Anny Silva Adri

Abstract Major depressive disorder (MDD) involves both central nervous system dysfunction and systemic immune alterations. Using a systems biology approach, we investigated whether peripheral leukocytes exhibit transcriptional changes in genes annotated to synaptic processes, molecular functions typically associated with neurons but also possibly implicated in immune cell biology.

1 Introduction Hepatitis is a systemic disease characterized by liver inflammation, which can be caused by hepatitis viruses (HAV, HBV, HCV, HDV, and HEV), alcohol-related liver damage, autoimmune hepatitis, or even excessive cigarette use [1-4]. In severe cases, it can progress to hepatocellular carcinoma (HCC), a condition often associated with delayed diagnosis and the appearance of extrahepatic symptoms [5].

Abstract Major depressive disorder (MDD) is a complex psychiatric condition with a significant global impact. This study applied a genomic-driven integrative systems neuroimmunology approach to analyze transcriptomic data from 3,114 individuals (1,877 MDD patients and 1,237 controls). The analysis revealed neuroimmunological transcriptomic alterations, indicating cross-talk between the immune and nervous systems in peripheral blood mononuclear cells (PBMCs) and specific brain regions.