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Leonardo Luís Artico on Muck Rack

Leonardo Luís Artico

As seen in: MDPI, Cell Press
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Articles

Endoplasmic reticulum architecture in liver metabolic regulation

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By Leonardo Luís Artico, Sophia Hakam, Güneş Parlakgul, Ana Paula Arruda
| Cell Press Verified
Keywords endoplasmic reticulum liver hepatocytes metabolism lipids organelle contacts Spatial and functional compartmentalization of hepatocyte metabolism The ability of cells and tissues to sense, integrate, and adapt to fluctuations in nutrient availability is fundamental to organismal homeostasis and survival. Among metabolic tissues, the liver plays a central role in coordinating whole-body energy balance [1,2].
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CaMKIIβ Ca2+ptures ER signals to initiate autophagosome biogenesis

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By Leonardo Luís Artico, Ana Paula Arruda
| Cell Press Verified
Get full text access Log in, subscribe or purchase for full access. References 1. Zheng, Q. ∙ Zhang, H. ∙ Zhao, H. ... Ca2+/calmodulin-dependent protein kinase II β decodes ER Ca2+ transients to trigger autophagosome formation Mol. Cell. 2024; 85:620-637.e6 2. Dikic, I. ∙ Elazar, Z. Mechanism and medical implications of mammalian autophagy Nat. Rev. Mol. Cell Biol. 2018; 19:349-364 3. Nakatogawa, H. Mechanisms governing autophagosome biogenesis Nat. Rev. Mol. Cell Biol. 2020; 21:439-458 4. Karanasios, E.
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IGFBP7 Fuels the Glycolytic Metabolism in B-Cell Precursor Acute Lymphoblastic Leukemia by Sustaining Activation of the IGF1R-Akt-GLUT1 Axis

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By Juliana Silveira Ruas, Leonardo Luís Artico, Natacha Azussa Migita, Gustavo Seguchi
| MDPI
Abstract : Increased glycolytic metabolism plays an important role in B-cell precursor Acute Lymphoblastic Leukemia (BCP-ALL). We previously showed that IGFBP7 exerts mitogenic and prosuvival effects in ALL by promoting IGF1 receptor (IGF1R) permanence on the cell surface, thus prolonging Akt activation upon IGFs/insulin stimulation.
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