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Leyin Wu on Muck Rack

Leyin Wu

As seen in: The Journal of Clinical Investigation
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Articles

FAM117B promotes gastric cancer growth and drug resistance by targeting the KEAP1/NRF2 signaling pathway

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By Yunjiang Zhou, Yaxin Chen, Yongwei Shi, Leyin Wu
| The Journal of Clinical Investigation
Abstract Gastric cancer often shows malignant growth and insensitivity to chemotherapeutic drugs due to the regulation of complex molecular mechanisms, which results in poor prognosis for patients. However, the relevant molecular mechanisms remain unclear. In this study, we reported that family with sequence similarity 117, member B (FAM117B), promoted the growth of gastric cancer cells and reduced the sensitivity of cells to chemotherapeutic drugs.
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