Leying Chen

CFHR-TCM: a co-occurrence feature-enhanced deep learning framework for personalized herb recommendation in traditional Chinese medicine 1School of Informatics, Hunan University of Chinese Medicine, Changsha, Hunan, China 2Information Center, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China DOI 10.7717/peerj-cs.4146 Academic Editor Alessio Bechini Subject Areas Bioinformatics, Computational Biology, Artificial Intelligence, Data Mining and Machine Learning,...

Abstract While intestinal stem cells (ISC) are essential for epithelial homeostasis, their dynamic regulation during immune-mediated injury remains undefined. Here we show that suppression of jejunal ISC proliferation contributes to pathology arising from oral EGFR (epidermal growth factor receptor) tyrosine kinase inhibitor (TKI) treatment.

Editor’s summary Epidermal growth factor receptor inhibitors (EGFRis) are used to treat several common cancers, but EGFRi use is frequently complicated by a skin rash that shows limited response to current treatments. Here, You et al. conducted a transcriptomic analysis of the skin of rats exposed to an EGFRi to uncover early changes preceding rash development, finding early activation of keratinocytes that led to activation of the JAK-STAT pathway and recruitment of inflammatory cells.