Li-Da Su

1 Introduction Fragile X syndrome (FXS) is an inherited neurodevelopmental disorder characterized by a spectrum of clinical manifestations, including cognitive impairments.[1] The absence of the fragile X mental retardation protein (FMRP) caused by mutations in the Fmr1 gene has been recognized as a causative factor for FXS.[2] Consequently, Fmr1-KO mice are widely used as an animal model for investigating the pathophysiological mechanisms underlying FXS.[3] Emerging evidence indicates that...

Abstract Bleeding and thrombosis are known as common complications of polycythemia for a long time. However, the role of coagulation system in erythropoiesis is unclear. Here, we discover that an anticoagulant protein tissue factor pathway inhibitor (TFPI) plays an essential role in erythropoiesis via the control of heme biosynthesis in central macrophages. TFPI levels are elevated in erythroblasts of human erythroblastic islands with JAK2V617F mutation and hypoxia condition.