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Shibo Ying on Muck Rack

Shibo Ying

As seen in: Nature, Taylor & Francis Online
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Articles

Potential roles and mechanisms of bacterial peptidylarginine deiminase in dental biofilm mediated by Porphyromonas gingivalis

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By Yitong Chen, Jiale Lou, Ying Fang, Shibo Ying
| Taylor & Francis Online
Abstract Background Porphyromonas gingivalis, a keystone oral pathogen, secretes the enzyme peptidylarginine deiminase (PPAD), which catalyzes protein citrullination and is implicated in both dental biofilm formation and the pathogenesis of systemic inflammatory diseases.
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TFPI from erythroblasts drives heme production in central macrophages promoting erythropoiesis in polycythemia - Nature Communications

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By Qi Zhang, Tingbo Liang, Li-Da Su, Tongyao Shang, Shibo Ying
| Nature Verified
Abstract Bleeding and thrombosis are known as common complications of polycythemia for a long time. However, the role of coagulation system in erythropoiesis is unclear. Here, we discover that an anticoagulant protein tissue factor pathway inhibitor (TFPI) plays an essential role in erythropoiesis via the control of heme biosynthesis in central macrophages. TFPI levels are elevated in erythroblasts of human erythroblastic islands with JAK2V617F mutation and hypoxia condition.
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