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Highlights • Functional connectivity between cerebellum and amygdala correlated with anxiety • Cerebellar DN glutamatergic neurons directly innervate and excite CeL PKCδ+ neurons • Motor activity activates the cerebello-amygdalar circuit to ameliorate anxiety • Challenging movement recruits PFA-DN orexinergic projection to drive the DN-CeL circuit Summary Physical exercise is known to reduce anxiety, but the underlying brain mechanisms remain unclear.
Aim. We sought to profile gut microbiota’s role in combination of Bu Fei Hua Yu (BFHY) with cisplatin treatment. Methods. Non-small cell lung cancer (NSCLC) mice model were constructed followed by treatment with cisplatin alone or combined with BFHY. Mice weight and tumor volume were measured during the experiment. And mice cecum were detected by hematoxylin and eosin, cecum contents were collected for Enzyme Linked ImmuneSorbent Assay, and stool were profiled for metagenomic sequencing. Results.
Targeting presynaptic H3 heteroreceptor in nucleus accumbens to improve anxiety and obsessive-compulsive-like behaviors Xiao-Yang Zhang, Shi-Yu Peng, Li-Ping Shen, Qian-Xing Zhuang, Bin Li, Shu-Tao Xie, Qian-Xiao Li, Ming-Run Shi, Tian-Yu Ma, Qipeng Zhang, Jian-Jun Wang, Jing-Ning Zhu Proceedings of the National Academy of Sciences Nov 2020, 202008456; DOI: 10.1073/pnas.2008456117
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