Li-Ying Yu
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Small molecule activation of m6A mRNA methylation as a novel approach for neuroprotection
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MANF regulates neuronal survival and UPR through its ER-located receptor IRE1α
Introduction The endoplasmic reticulum (ER) is the largest intracellular compartment in most eukaryotic cells, dealing with protein secretion and folding as well as lipid biosynthesis and calcium homeostasis. Overloading ER with unfolded or misfolded proteins activates a signaling machinery called unfolded protein response (UPR). 1 The unfolded protein response: from stress pathway to homeostatic regulation.
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