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Liam Bolt

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Articles by Liam Bolt

Author Correction: Spatially resolved multiomics of human cardiac niches - Nature

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By Kazumasa Kanemaru, James Cranley, Siew Yen Ho, Krzysztof Polanski, Laura Richardson, Natsuhiko Kumasaka, Yue Qin, Claudia I. Semprich, Lukas Mach, Liam Bolt, Lira Mamanova, Rakeshlal Kapuge, Sam Barnett, Carlos Talavera-López, Ilaria Mulas, Krishnaa T. Mahbubani, Lu Wang, Martin Prete, Kourosh Saeb-Parsy, Norbert Hubner, Rasheda A. Chowdhury, Michela Noseda
| Nature Verified
Correction to: Nature https://doi.org/10.1038/s41586-023-06311-1 Published online 12 July 2023 In the drug2cell analysis of the initially published article, there was an error in filtering drug and target interactions. The activity (pChEMBL) threshold for these interactions was specifically set for each family of target molecules in accordance with the Illuminating the Druggable Genome (IDG) project. In the original manuscript, there was a discrepancy with the values from the IDG project1.
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Author Correction: Human SARS-CoV-2 challenge uncovers local and systemic response dynamics - Nature

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By Kaylee B. Worlock, Lisa M Dratva, Masahiro Yoshida, Helen R. Wagstaffe, Laura Richardson, Josephine Barnes, Lorenz Kretschmer, Krzysztof Polanski, Jessica Allen-Hyttinen, Puja A. Mehta, Jacqueline M. Boccacino, Waradon Sungnak, Rasa Elmentaite, Ni Huang, Rakesh Kapuge, Liam Bolt, Elena Prigmore, Leo Swadling, Claire Smith, Vitor H. Teixeira, Vítor Teixeira, Sam M. Janes, Rachel Chambers Verified, Muzlifah Haniffa, Robert S Heyderman, Mahdad Noursadeghi, Benny Chain, Andreas Mayer, Kerstin B Meyer, Christopher J Chiu, Marko Nikolic
| Nature Verified
Correction to: Nature https://doi.org/10.1038/s41586-024-07575-x Published online 19 June 2024 In the version of the article initially published, the Acknowledgements was missing the following text, which has now been added to the HTML and PDF versions of the article: “The authors gratefully acknowledge support from the UK Vaccine Taskforce of the Department of Business, Energy and Industrial Strategy of Her Majesty’s Government (BEIS).
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Human SARS-CoV-2 challenge uncovers local and systemic response dynamics - Nature

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By Kaylee B. Worlock, Lisa M Dratva, Masahiro Yoshida, Helen R. Wagstaffe, Laura Richardson, Josephine Barnes, Lorenz Kretschmer, Krzysztof Polanski, Jessica Allen-Hyttinen, Puja A. Mehta, Jacqueline M. Boccacino, Waradon Sungnak, Rasa Elmentaite, Ni Huang, Rakesh Kapuge, Liam Bolt, Elena Prigmore, Leo Swadling, Claire Smith, Vitor H. Teixeira, Vítor Teixeira, Sam M. Janes, Rachel Chambers Verified, Muzlifah Haniffa, Robert S Heyderman, Mahdad Noursadeghi, Benny Chain, Andreas Mayer, Kerstin B Meyer, Christopher J Chiu, Marko Nikolic
| Nature Verified
Abstract The COVID-19 pandemic is an ongoing global health threat, yet our understanding of the dynamics of early cellular responses to this disease remains limited1. Here in our SARS-CoV-2 human challenge study, we used single-cell multi-omics profiling of nasopharyngeal swabs and blood to temporally resolve abortive, transient and sustained infections in seronegative individuals challenged with pre-Alpha SARS-CoV-2.
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Author Correction: Age-specific nasal epithelial responses to SARS-CoV-2 infection - Nature Microbiology

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By Kaylee B. Worlock, Masahiro Yoshida, Krzysztof Polanski, Liam Bolt, Laura Richardson, Machaela Palor, Thomas Burgoyne, Andreia Pinto, Dale Moulding, Timothy McHugh, Eliz Kilich, Puja A. Mehta, Wendy Barclay, Paolo De Coppi, Judith Breuer, Rachel Chambers Verified, Sarah A Teichmann, Kerstin B Meyer, Marko Nikolic
| Nature Verified
Correction to: Nature Microbiology https://doi.org/10.1038/s41564-024-01658-1, published online 15 April 2024 In the version of the article initially published, Paolo De Coppi’s surname originally appeared as “DeCoppi”. In the third paragraph of the article, the callout to Extended Data Fig. 3i has been amended from Extended Data Fig. 4i. In the legend to Fig. 6, the description of panel m (“Summary figure highlighting the key findings from the study.
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Human skeletal muscle aging atlas - Nature Aging

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By Veronika R. Kedlian, Tianliang Liu, Liam Bolt, Elena Prigmore, Jan Patrick Pett, Lu Yang, Krzysztof Polanski, Omer Ali Bayraktar, Krishnaa T. Mahbubani, Andy Xiang, Kerstin B Meyer, Kourosh Saeb-Parsy, Sarah A Teichmann, Catherine Tudor, Eirini S. Fasouli, Nana-Jane Chipampe
| Nature Verified
Abstract Skeletal muscle aging is a key contributor to age-related frailty and sarcopenia with substantial implications for global health. Here we profiled 90,902 single cells and 92,259 single nuclei from 17 donors to map the aging process in the adult human intercostal muscle, identifying cellular changes in each muscle compartment. We found that distinct subsets of muscle stem cells exhibit decreased ribosome biogenesis genes and increased CCL2 expression, causing different aging phenotypes.
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Age-specific nasal epithelial responses to SARS-CoV-2 infection - Nature Microbiology

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By Kaylee B. Worlock, Masahiro Yoshida, Krzysztof Polanski, Liam Bolt, Laura Richardson, Machaela Palor, Thomas Burgoyne, Andreia Pinto, Dale Moulding, Timothy McHugh, Eliz Kilich, Puja A. Mehta, Wendy Barclay, Judith Breuer, Rachel Chambers Verified, Sarah A Teichmann, Kerstin B Meyer, Marko Nikolic, Paolo DeCoppi
| Nature Verified
Abstract Children infected with SARS-CoV-2 rarely progress to respiratory failure. However, the risk of mortality in infected people over 85 years of age remains high. Here we investigate differences in the cellular landscape and function of paediatric (<12 years), adult (30–50 years) and older adult (>70 years) ex vivo cultured nasal epithelial cells in response to infection with SARS-CoV-2.
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A human embryonic limb cell atlas resolved in space and time - Nature

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By Bao Zhang, Peng He, Brian Williams, Kenny Roberts, Liam Bolt, Krzysztof Polanski, Rasa Elmentaite, Martin Prete, Raphael Blain, Alain Chédotal, Omer Ali Bayraktar, John C Marioni, Barbara J. Wold, Hongbo Zhang
| Nature Verified
Abstract Human limbs emerge during the fourth post-conception week as mesenchymal buds, which develop into fully formed limbs over the subsequent months1. This process is orchestrated by numerous temporally and spatially restricted gene expression programmes, making congenital alterations in phenotype common2.
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Spatially resolved multiomics of human cardiac niches - Nature

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By Kazumasa Kanemaru, James Cranley, Siew Yen Ho, Krzysztof Polanski, Laura Richardson, Natsuhiko Kumasaka, Yue Qin, Claudia I. Semprich, Lukas Mach, Lira Mamanova, Sam Barnett, Carlos Talavera-López, Krishnaa T. Mahbubani, Lu Wang, Martin Prete, Kourosh Saeb-Parsy, Norbert Hubner, Rasheda A. Chowdhury, Liam Bolt, Rakeshlal Kapuge, Ilaria Mulas, Michela Noseda
| Nature Verified
Abstract The function of a cell is defined by its intrinsic characteristics and its niche: the tissue microenvironment in which it dwells. Here we combine single-cell and spatial transcriptomics data to discover cellular niches within eight regions of the human heart. We map cells to microanatomical locations and integrate knowledge-based and unsupervised structural annotations. We also profile the cells of the human cardiac conduction system1.
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