Lian Ni Lee

Abstract Protein arginine methyltransferase (PRMT) 5 is over-expressed in a variety of cancers and the master transcription regulator E2F1 is an important methylation target. We have explored the role of PRMT5 and E2F1 in regulating the non-coding genome and report here a striking effect on long non-coding (lnc) RNA gene expression. Moreover, many MHC class I protein-associated peptides were derived from small open reading frames in the lncRNA genes.

Abstract Protein acetylation plays a key role in regulating cellular processes and is subject to aberrant control in diverse pathologies. Although histone deacetylase (HDAC) inhibitors are approved drugs for certain cancers, it is not known whether they can be deployed in other therapeutic contexts. We have explored the clinical HDAC inhibitor, zabadinostat/CXD101, and found that it is a stand-alone regulator of the adaptive immune response.

MCMV Infection Induces Three Subsets Based on CX3CR1 Expression Levels in Conventional and Inflating Virus-Specific CD8+ Tmem Cells CD8+ T Cells in Tissues Are CX3CR1hi in the Setting of Persistent Antigen CX3CR1 Is Required for Optimal Inflating T Cell Memory Responses following Ad-lacZ Immunization Distribution and Phenotype of Three CX3CR1 Subsets in Human CD8+ T Cells Detection and Analysis of Virus and Vaccine-Specific T Cells The induction and maintenance of robust CD8+ T cell memory...