Libing Song

Abstract Ferroptosis is an iron-dependent form of cell death driven by lipid peroxidation1. Here we identify spermine—a polyamine derived from spermidine2—as an endogenous iron chelator that directly suppresses ferroptosis.

Keywords PRDX6 lysophospholipids membrane translocation of GPX4 cancer therapy Get full text access Log in, subscribe or purchase for full access. References 1. Yin, H. ∙ Xu, L. ∙ Porter, N.A. Free radical lipid peroxidation: mechanisms and analysis Chem. Rev. 2011; 111:5944-5972 2. Gaschler, M.M. ∙ Stockwell, B.R. Lipid peroxidation in cell death Biochem. Biophys. Res. Commun. 2017; 482:419-425 3. Agmon, E. ∙ Solon, J. ∙ Bassereau, P. ...

June 15, 2025 | Ophthalmology Objective To investigate the vascular characteristic changes in the macular retina and choriocapillaris, as well as the choroidal vascularization of eyes with different degrees of myopia in juveniles using Swept-source Optical Coherence Tomography (SS-OCT), aiming to understand the pathophysiological characteristics of myopic eyes further.