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Articles by Libo Wang
A rapid silver nitrate histological staining technique for studying the osteocyte lacunocanalicular system
Abstract The osteocyte lacuno-canalicular system (LCS) is a fundamental bone structure that plays a critical role in maintaining skeletal health and systemic mineral homeostasis. However, investigations into the functional and morphological properties of the LCS have been hindered by the lack of a rapid and reliable histological staining method.
Sitagliptin, a repurposed diabetes drug, overcomes gemcitabine resistance in pancreatic cancer via ribonucleotide reductase inhibition: SITGEM-CARE phase 2 trial
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Abstract Gemcitabine resistance remains a major therapeutic barrier in pancreatic ductal adenocarcinoma (PDAC), for which median survival in advanced disease has remained near one year despite extensive clinical investigation. Using artificial intelligence (AI)-guided structure-based drug repurposing, we identified sitagliptin, a DPP-4 inhibitor for diabetes, as a candidate ribonucleotide reductase (RRM1/2) inhibitor that sensitizes PDAC to gemcitabine.
By Jun Yu, Mengyu Li, Qingxiao Fang, Jingrui Yan, Yunfeng Zhang, Ziyun Liu, Zekun Li, Libo Wang, Zongjing Lv, Yadi Wang, Tao Wang, Zhen Zhao, Xiaoqing Ma, Jin Zhang, Guanpeng Xie, Huihui Sun, Ningning Zhao, Antao Chang, Yukuan Feng, Hongwei Wang, Xingyun Chen, Yuexiang Liang, Tiansuo Zhao, Jian Wang, Weidong Ma, Chuntao Gao, Song Gao, Bin Wang, Yongjie Xie, Tianxing Zhou, Xiuchao Wang, Jihui Hao, Shangheng Shi
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Nature
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Bridging the medical cliff: a paediatric–adult continuity of care model for 2,341 young adults with rare diseases in China
Abstract Introduction: Adolescents and young adults with rare diseases face a “medical cliff” when they age out of paediatric services, losing established care relationships and disease-specific expertise. Most rare diseases begin in childhood, since 69.9% of catalogued rare diseases are of exclusively paediatric onset. The problem is acute in China, where an estimated 20 million people live with a rare disease and systematic transitional care pathways remain largely absent.
Broadband low-frequency sound absorption and high insulation in a clay-cement composite with hydrogel-foaming engineered gradient porosity
Abstract Urban noise pollution has emerged as a critical environmental issue, driving demand for high-performance cementitious materials with broadband sound absorption capabilities. Conventional porous concrete, characterized by uniform pore distribution, suffers from narrow absorption bandwidth and low sound insulation, limiting its practical application in architectural acoustics.
Sea level controls terrigenous sediment provenance evolution in the Okinawa Trough since the Last Glacial Maximum
Abstract The Okinawa Trough (OT), a typical back-arc basin in the western Pacific, preserves continuous sedimentary records since the Quaternary, making it a critical area for investigating sea-level changes, source-to-sink processes, and paleoclimate evolution. However, the controlling mechanisms of terrestrial input to the trough since the Last Glacial Maximum (LGM) remain insufficiently understood.
A MWCNT-PVDF/PCL Piezo‐Triboelectric Coupled Nanogenerator by Synergistic Regulation of Microcrystalline Phase and Patterned Structure for Self‐Powered Sensors - Li - Small - Wiley Online Library
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description smll72682-sup-0001-SuppMat.docx7.3 MB Supporting File 1: smll72682-sup-0001-SuppMat.docx. smll72682-sup-0002-VideoS1.mp41.9 MB Supporting File 2: smll72682-sup-0002-VideoS1.mp4.
Lung-Targeted Lipid Nanoparticles Delivery of Wogonin for Pulmonary Fibrosis in Mice via Modulation of Cellular Proteostasis
Back to Journals » International Journal of Nanomedicine » Volume 21 Authors Wang L, Lin F, Gao F, Jia Z, Liu J, Liu X, Shang J, Ru X, Zhao Y, Zhao T, Yang L, Guo Y, Zhang M Received 30 January 2026 Accepted for publication 29 April 2026 Published 6 May 2026 Volume 2026:21 591490 DOI https://doi.org/10.2147/IJN.S591490 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Prof.
Investigation of the Solubility Behavior of Tetramethylthiuram Disulfide in 12 Pure Solvents from 283.15 to 323.15 K: Solid-Liquid Equilibrium Determination and Model Correlation
Cite Jump to ExpandCollapse Solid-Solid Equilibria and Solid-Fluid EquilibriaJanuary 20, 2026 Investigation of the Solubility Behavior of Tetramethylthiuram Disulfide in 12 Pure Solvents from 283.15 to 323.15 K: Solid-Liquid Equilibrium Determination and Model Correlation Click to copy article linkArticle link copied! Jingxuan Qiu* Jingxuan Qiu Institute of Chemical and Industrial Bioengineering, School-Enterprise Joint Technology Innovation Laboratory of Novel Molecular Functional Materials...
Pharmacological Enhancement of Integrated Stress Response Confers Protection in Calcific Aortic Valve Disease:
JACC Journals › JACC: BTS › Archives › Vol.
Confined Construction of Artificial Electron Transfer Pathways in Cell Wall Mesopores for Enhanced Oxygen Reduction Reaction at Microbial Cathodes
Conflict of Interest The authors declare no conflict of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description adfm73111-sup-0001-SuppMat.docx8 MB Supporting Information References 1, Nat. Energy 2017, 2, 17093. 2, , Science 2012, 337, 686. 3, , Chem. Soc. Rev. 2010, 39, 4433. 4, , , , , , , , , Coord. Chem. Rev. 2024, 517, 216019. 5, , , , , , , Nat. Sustain.
Licochalcone A in Folic Acid‐targeted Nanoparticles for Precise Anticancer Effects in Breast Cancer
Conflicts of Interest The authors declare that there are no conflicts of interest. Supporting Information Filename Description cbdv70273-sup-0001-SuppMat.pdf561.3 KB Supporting file 1: cbdv70273-sup-0001-SuppMat.pdf References 1, , , et al., “Chalcones Repressed the AURKA and MDR Proteins Involved in Metastasis and Multiple Drug Resistance in Breast Cancer Cell Lines,” Molecules (2018): 23. 2, , , , and , “Effect of BRCA Germline Mutations on Breast Cancer Prognosis,” Medicine (2016): 95.
Enhancement of built-in electric field strength of BiOCl/NMT Z-scheme heterojunctions through photoinitiated defects for optimized photocatalytic performance
Enhancement of built-in electric field strength of BiOCl/NMT Z-scheme heterojunctions through photoinitiated defects for optimized photocatalytic performance† Facilitating carrier migration within Z-scheme heterojunctions is essential for improving the efficiency of photocatalytic nitrogen fixation. Herein, we successfully constructed BiOCl/NMT Z-scheme heterojunctions by a simple solvothermal process and adsorption–deposition methods.
Synergy of sp2-hybridized carbon doping and photogenerated surface oxygen vacancies for the enhanced photocatalytic performance of BiOCl and solvent effects
Synergy of sp2-hybridized carbon doping and photogenerated surface oxygen vacancies for the enhanced photocatalytic performance of BiOCl and solvent effects† It is an urgent task to develop highly efficient photocatalysts to achieve rapid treatment of water pollutants. Carbon doping, especially using sp2 hybridized carbon, which has rarely been studied, can offer new adsorption sites and improve light utilization.
A morphology modulation strategy to construct Z-scheme WO3/Fe-W18O49 heterojunctions with tunable nanowire size for efficient photocatalytic nitrogen fixation
A morphology modulation strategy to construct Z-scheme WO3/Fe-W18O49 heterojunctions with tunable nanowire size for efficient photocatalytic nitrogen fixation† Ammonia occupies a vital position in the development of human society. The synthesis of NH3 depends primarily on the Haber–Bosch process, in which N2 and H2 are reacted at high temperatures, high pressures, and in the presence of a catalyst.
Preparation, Characterization and Bioactivities of Strawberry Polysaccharides
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Optimization of load-bearing parameters for anisotropic nodes and prefabricated wall panels in prefabricated shear wall structures
Citation: Zhao J, Wang L, Ma T (2025) Optimization of load-bearing parameters for anisotropic nodes and prefabricated wall panels in prefabricated shear wall structures. PLoS ONE 20(3): e0318521. https://doi.org/10.1371/journal.pone.0318521 Editor: Saeed Banihashemi, University of Technology Sydney, AUSTRALIA Received: July 2, 2024; Accepted: January 16, 2025; Published: March 17, 2025 Copyright: © 2025 Zhao et al.
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Pd Nanoparticles Immobilized on Pyridinic N-Rich Carbon Nanosheets for Promoting Suzuki Cross-Coupling Reactions
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
AoI Analysis of Satellite-UAV Synergy Real-Time Remote Sensing System
1. Introduction In recent years, as the space–air–ground integrated network (SAGIN) improves by leaps and bounds, the utilization of platforms such as low Earth orbit (LEO) satellites and unmanned aerial vehicles (UAVs) to provide environmental remote sensing and monitoring services is of significant importance [1]. Specifically, LEO satellites and UAVs are configured with sensing equipment that collects environmental status information such as images and videos.
Review on the Collaborative Research of Water Resources-Water Environment-Water Ecology in Hulun Lake
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Creep Failure Characteristics and Mathematical Modeling of High-Density Polyethylene Geomembranes under High Stress Levels
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Monitoring of Low Chl-a Concentration in Hulun Lake Based on Fusion of Remote Sensing Satellite and Ground Observation Data
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
In Situ Nondestructive Detection of Nitrogen Content in Soybean Leaves Based on Hyperspectral Imaging Technology
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
RF Interconnection Design of Bump Bonding with a Dislocation Package Structure towards Electro-Optic Modulation Applications
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Microstructural Inhomogeneity in the Fusion Zone of Laser Welds
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Revisiting the Boomerang Attack from a Perspective of 3-differential
Paper 2023/1689 , University of Hyogo, Kobe, Japan , Jinan University, Guangzhou, China , Institute of Information Engineering, CAS, Beijing, China; School of Cyber Security, UCAS, Beijing, China , University of Hyogo, Kobe, Japan , University of Hyogo, Kobe, Japan; NICT, Tokyo, Japan In this paper, inspired by the work of Beyne and Rijmen at CRYPTO 2022, we explore the accurate probability of $d$-differential in the fixed-key model.
Advances in the role of epigenetics in homocysteine-related diseases
The authors thank their funding sources, the Provincial Ministry of Medical Science and Technology Tackling Program of Henan Province (no. SB201901060). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
Emulsifying properties of plant-derived polypeptide and their conjugates: A self consistent-field calculation study of the impact of hydrolysis
Emulsifying properties of plant-derived polypeptide and their conjugates: A self consistent-field calculation study of the impact of hydrolysis By considering the hydrolysates of soy protein produced by trypsin as an example, the emulsion stabilizing properties of plant-based protein fragments have been investigated theoretically.
Catalpol inhibits HHcy-induced EndMT in endothelial cells by modulating ROS/NF-κB signaling
Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.
Factors affecting myopia progression of orthokeratology
Back to Journals » Nature and Science of Sleep » Volume 15 Authors Yu D, Wang L, Zhou X , Liu L, Wu S, Tang Q, Zhang X Received 15 May 2023 Accepted for publication 14 November 2023 Published 29 November 2023 Volume 2023:15 Pages 993—1001 DOI https://doi.org/10.2147/NSS.S421407 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Valentina Alfonsi Dongyi Yu,1,2,* Libo Wang,2,* Xin Zhou,2,* Lili Liu,2 Shuang...
Selective Ethylene Tetramerization: An Overview
Selective Ethylene Tetramerization: An Overview Biao-Biao Hao, Fakhre Alam, Yan Jiang, Libo Wang, Haonan Fan, Ma Jing, Yanhui Chen, Yating Wang and Tao Jiang Abstract With greater market demand, interest in the selective production of linear α-olefins has been increasing.
The signature of pyroptosis-related gene prognostic and immune microenvironment in adrenocortical carcinoma
1 Introduction Adrenocortical carcinoma (ACC), also known as adrenocortical adenocarcinoma or cortical carcinoma, is a malignant epithelial tumor originating from adrenal cortical cells. Although the incidence of ACC is low, about 0.7-2 cases per 100,000 people per year, the clinical manifestations of ACC are complex and diverse.
Coefficient Grouping: Breaking Chaghri and More
Paper 2022/991 Coefficient Grouping: Breaking Chaghri and More Abstract We propose an efficient technique called coefficient grouping to evaluate the algebraic degree of the FHE-friendly cipher Chaghri, which has been accepted for ACM CCS 2022. It is found that the algebraic degree increases linearly rather than exponentially.
Accuracy of Ultrasound Jugular Venous Pressure Height in Predicting Central Venous Congestion
LettersMay 2022 Author, Article and Disclosure Information IN RESPONSE: The observation that a single cutoff for uJVP does not fully describe the complete receiver-operating characteristic profile of our validated ultrasound examination is astute. Physical examinations traditionally are taught in a simplistic manner with dichotomized cutoffs (such as traditional JVP), which is the reason for our more simplistic presentation of a singular cutoff.
Comprehensive machine-learning survival framework develop a consensus model in large scale multi-center cohorts for pancreatic cancer
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Correction: Accuracy of Ultrasound Jugular Venous Pressure Height in Predicting Central Venous Congestion
The authors of a recent article (1) have noted an error in the first paragraph of their Results section. The fifth sentence incorrectly stated, “More than half (56%) had reduced left ventricular ejection fraction (<50%) … .” The correct statement is as follows: “More than half (56%) had preserved left ventricular ejection fraction (≥50%) … .” The results and key findings of the article remain unchanged. The online version has been corrected. Reference 1. Wang L , Harrison J , Dranow E , et al.
High-efficiency counter electrodes for quantum dot-sensitized solar cells (QDSSCs): Designing Graphene-supported CuCo2O4 porous hollow microspheres with improved electron transport performance
High-efficiency counter electrodes for quantum dot-sensitized solar cells (QDSSCs): Designing Graphene-supported CuCo2O4 porous hollow microspheres with improved electron transport performance Owing to its low-cost, eco-friendly and multiple oxidation states, the ternary transition metal oxide CuCo2O4 has been used as an electrode material with superior electrocatalytic activity in numerous fields, whereas its application in quantum dot-sensitized solar cells (QDSSCs) has not been investigated.
Accuracy of Ultrasound Jugular Venous Pressure Height in Predicting Central Venous Congestion
Affiliations: Division of Cardiovascular Medicine, University of Utah School of Medicine, Salt Lake City, Utah (L.W., J.H., E.D.) Department of Medicine, Duke University Medical Center, Durham, North Carolina (N.A.) Division of Cardiovascular Medicine, University of Utah School of Medicine, and George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah (L.K.).
In situ Irradiated XPS Investigation on S‐Scheme TiO2@ZnIn2S4 Photocatalyst for Efficient Photocatalytic CO2 Reduction
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202103447-sup-0001-SuppMat.pdf1.7 MB Supporting Information References 1, , , , , , Adv. Mater. 2021, 33, 2003521. 2, , , Chem. Soc. Rev. 2020, 49, 6579. 3, , , , , , , Angew. Chem., Int. Ed. 2018, 57, 7610. 4, , , , , , , Chem. Soc. Rev. 2020, 49, 2937. 5, , , , , , , , Joule 2019, 3, 2792. 6, , , , , , Acta Phys.-Chim. Sin. 2020, 36, 1906014. 7, , , , , , , Nat. Commun. 2019, 10, 3169.
Constructing electron transfer pathways and active centers over W18O49 nanowires by doping Fe3+ and incorporating with g-C3N5 for enhanced photocatalytic nitrogen fixation
Constructing electron transfer pathways and active centers over W18O49 nanowires by doping Fe3+ and incorporating with g-C3N5 for enhanced photocatalytic nitrogen fixation Global warming actuates us to seek a sapiential strategy to replace the energy consumption of Haber-Bosch approach in manufacture ammonia territory. NH3 was utilized in agriculture to produce fertilizer to gratify the rapid increase of human food demanding.
Developing a New Carrier Protein for Conjugate Vaccines: Analytical Strategies for Similarity Testing and Formulation Development
Conjugate vaccines are developed by linking molecules that are poorly immunogenic to a carrier protein to improve immunogenicity. They can be highly effective, as exemplified by the Haemophilus Influenzae b (Hib) and Prevnar 13® (which prevents infections from pneumococcal bacteria) vaccines, both of which are conjugates. However, conjugate vaccines are complex to formulate and costly, with very few carrier proteins licensed for use.
WC and Cobalt nanoparticles embedded nitrogen-doped carbon 3D nanocage derived from H3PW12O40@ZIF-67 for photocatalytic nitrogen fixation
WC and Cobalt nanoparticles embedded nitrogen-doped carbon 3D nanocage derived from H3PW12O40@ZIF-67 for photocatalytic nitrogen fixation Ammonia is a momentous chemical raw in modern life, but the application of green and environment-friendly way to manufacture ammonia is remained an enormous dilemma that requests to be conquer at this stage.
Deep learning surrogate model for kinetic Landau-fluid closure with collision
Compared with kinetic or gyrokinetic models, fluid or gyro-fluid models are adequate and much more cost-effective for turbulence and transport studies in certain parameter regimes.11. M. Francisquez, T. N. Bernard, B. Zhu, A. Hakim, B. N. Rogers, and G. W. Hammett, “Fluid & gyrokinetic turbulence in open field-line, helical plasmas,” arXiv:2002.11136 (2020). In principle, a fluid model consists of three parts: the moment equations, the field equations, and the closure.
Clinical and Genetic Spectrum of Children with Primary Ciliary Dyskinesia in China
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Figure 1 online only. Flow chart of patient's enrollment and the diagnostic tests performed. PCD, primary ciliary dyskinesia; HSVA, high-speed video analysis; nNO, nasal nitric oxide; TEM, transmission electron microscopy; NA, not available; inc*, inconclusive Figure 2 online only. Transmission electron microscopy images of primary ciliary dyskinesia defects.
An Alarming Trend
Atrial fibrillation (AF) is the most common, sustained arrhythmia worldwide, with similar lifetime risks for men and women.[1] Since women have longer life expectancies, they account for over half of AF patients, particularly in older populations.[2] Research suggests that women with AF tend to be more symptomatic, less responsive to pharmacotherapy, and report a lower quality of life.[3] It is therefore essential for the healthcare community not only to study AF therapies such as catheter...
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