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Lieberman-Aiden E on Muck Rack

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Strain- and plasmid-level deconvolution of a synthetic metagenome by sequencing proximity ligation products

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By Lee YK, Bin Mohamed Y, Gilbert JA, Lieberman-Aiden E
| PeerJ
Discussion This study demonstrates that Hi-C sequencing data provide valuable information for metagenome analyses that are not currently obtainable by other methods. By applying Hi-C to a synthetic microbial community we showed that genomic DNA was associated by Hi-C read pairs within strains orders of magnitude more frequently than between strains. Hi-C reads associated genomic regions at distances not achievable with mate-pair or long-read sequencing technologies.
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