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Lies Van den Eynde

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Patient-specific alterations in blood plasma cfRNA profiles enable accurate classification of cancer patients and controls - Communications Medicine

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By Annelien Morlion, Philippe Decruyenaere, Jasper Anckaert, Justine Nuytens, Eveline Vanden Eynde, Kimberly Verniers, Celine Everaert, Guy G. Brusselle, Steven Callens, Filomeen Haerynck, Dimitri Hemelsoet, Eric Hoste Verified, Jo Lambert, Nicolaas Lumen, Fritz Offner, Koen Paemeleire, Vanessa Smith, Jo Van Dorpe, Amber Vanhaecke, Hans Van Vlierberghe, An Mariman, Olivier Thas, Jo Vandesompele, Pieter Mestdagh, Kathleen Schoofs, Nickolas Johns Ramirez, Lies Van den Eynde
| Nature Verified
Abstract Circulating nucleic acids in blood plasma form an attractive, minimally invasive resource to study human health and disease. In this study, we aimed to identify cell-free RNA alterations that can distinguish cancer patients from cancer-free individuals. We first performed mRNA capture sequencing on 266 blood plasma samples from cancer patients and controls, including a discovery set of 208 donors across 25 cancer types and a replication set of 58 donors across three cancer types.
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