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Articles by Lin Leng
Evaluating orthokeratology lens fitting and the visual quality of artificial intelligence-fitted personalized lenses in myopic children with corneal asymmetry
Abstract To evaluate the orthokeratology (ortho-K) lens fitting and visual quality of artificial intelligence (AI) -fitted personalized lenses in myopic children with corneal asymmetry.This retrospective study included 139 children with corneal asymmetry who underwent ortho-K fitting, grouped according to conventional vision shaping treatment (VST) lenses (n = 53), corneal refractive therapy (CRT) lenses (n = 47), and AI-fitted personalized Optoshare Good Positioning (GP) lenses (n = 39).
How Foraging Mode Sculpts Sensory Systems: Morphological Evidence From DiceCT and Histology in Sympatric Lizards
1 Introduction The ability to sense changes in the environment is critical to the survival and reproduction of animals (Verwaijen and Van Damme 2007). Natural selection favors the evolution of sensory systems that show the best function in a given environment (Kimchi and Terkel 2001; Hagelin 2004), but there are also trade-offs between different sensory organs (Erudaitius et al. 2024).
A Small Molecule Allele-selective Transcriptional Inhibitor of the MIF Immune Susceptibility Locus
Abstract Functional variants of the gene for the cytokine macrophage migration inhibitory factor (MIF) are defined by a 4-nucleotide promoter microsatellite (-794 CATT5-8, rs5844572) and confer risk for autoimmune, infectious, and oncologic diseases. We describe herein the discovery of a prototypic, small molecule inhibitor of MIF transcription with selectivity for high microsatellite repeat number and correspondingly high gene expression.
High-Energy Supplemental Feeding Shifts Gut Microbiota Composition and Function in Red Deer (Cervus elaphus)
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Report of abnormal tail regeneration of Eremias yarkandensis (Sauria: Lacertidae) and its locomotor performance
1 INTRODUCTION The tail is a pivotal functional trait in reptiles, including lizards. It plays a crucial role in various aspects of their lives, such as visual displays, agonistic behavior, nutrition reserves (Chapple & Swain, 2002; Doughty et al., 2003), locomotor performance (Cromie & Chapple, 2012), and anti-predation strategies (Lin et al., 2017).
Urothelial Oxidative Stress and ERK Activation Mediate HMGB1-Induced Bladder Pain
3.1. Experiment 1: Changes in Bladder Oxidative Stress and ERK Phosphorylation by Intravesical HMGB1 in MIF KO Mice We examined changes in bladder levels of 4HNE as a marker for oxidative stress and ERK phosphorylation using both Western blotting and immunohistochemistry (IHC). Treatment with intravesical HMGB1 for 1 h resulted in an increase in levels of 4HNE in the bladder, as measured by Western blotting, when compared to intravesical treatment with PBS (Figure 3A).
The Influence of Accommodation on Retinal Peripheral Refraction Changes in Different Measurement Areas
Background. The change in refraction caused by accommodation inevitably affects the peripheral defocus state and thus may influence the effect of retinal peripheral myopic defocus measures in myopia control. This study investigated accommodation changes in different peripheral retinas under cycloplegia to help improve myopia control. Methods. Fifty-six eyes of fifty-six myopic subjects were recruited for this prospective study.
ICBP90 Regulates MIF Expression, Glucocorticoid Sensitivity, and Apoptosis at the , MIF Immune Susceptibility Locus
FULL LENGTH Jie Yao, Department of Laboratory Medicine and Medical Research Center, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, Guangdong, China These authors contributed equally to this work. Search for more papers by this author Lin Leng, Departments of Medicine and Pathology, Yale University School of Medicine, New Haven, CT, USA These authors contributed equally to this work.
The impact of cataract progression on accuracy of intraocular lens power measurement
Loading metrics Open Access Peer-reviewed Research Article Lin Leng, Honglei Li, Min Yin, Han Gao, Ting Shao, Keli Long Lin Leng, Honglei Li, Min Yin, Han Gao, Ting Shao, Keli Long Published: February 10, 2021 https://doi.org/10.1371/journal.pone.0246816 Figures Abstract Purpose The aim of this study was to assess the impact of cataract progression using the Haigis formula-calculated intraocular lens (IOL) power and investigate the accuracy of IOL power measured at different time points.
CD74-Downregulation of Placental Macrophage-Trophoblastic Interactions in Preeclampsia
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Methods and Results: We performed whole-genome expression analysis of placental tissue. CD74 was one of the most downregulated genes in placentas from preeclamptic women. By reverse transcriptase-polymerase chain reaction, we confirmed this finding in early-onset (<34 gestational week, n=26) and late-onset (≥34 gestational week, n=24) samples from preeclamptic women, compared with healthy pregnant controls (n=28). CD74 protein levels were analyzed by Western blot and flow cytometry.
By Herbert Schulz, Friedrich C. Luft, Dominik Müller, Lukasz Przybyl, Nadine Haase, Michaela Golic, Julianna Rugor, Maria Emilia Solano, Petra Clara Arck, Martin Gauster, Berthold Huppertz, Christoph Emontzpohl, Christian Stoppe, Jürgen Bernhagen, Lin Leng, Richard Bucala, Arnd Heuser, M. Susanne Weedon-Fekjær, Guro M. Johnsen, Dirk Peetz, Ralf Dechend
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