Linara Gabitova-Cornell on Muck Rack

Linara Gabitova-Cornell

As seen in: Cell Press
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Articles

Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer

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By Linara Gabitova-Cornell, Aizhan Surumbayeva, Suraj Peri, Bioinformatics Facility
| Cell Press
Highlights • Knockout of Nsdhl switches pancreatic carcinoma from glandular to basal • Statins or Nsdhl knockout activates SREBP1-dependent Tgfb1 expression and EMT • PDACs in patients receiving statins have enhanced mesenchymal features • LDL cholesterol in vitro or in patients antagonizes SREBP1 and autocrine TGF-β Summary Oncogenic transformation alters lipid metabolism to sustain tumor growth.
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