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Linchang Dai

As seen in: Cell Press, Cell Reports
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Articles by Linchang Dai

Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin

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By Linchang Dai, Yaxin Dai, Jinhua Han
| Cell Press Verified
Adamovich A.I. Banerjee T. Wingo M. Duncan K. Ning J. Martins Rodrigues F. Huang K.L. Lee C. Chen F. Ding L. Parvin J.D. Functional analysis of BARD1 missense variants in homology-directed repair and damage sensitivity. PLoS Genet. 2019; 15: e1008049 Adams P.D. Afonine P.V. Bunkóczi G. Chen V.B. Davis I.W. Echols N. Headd J.J. Hung L.-W. Kapral G.J. Grosse-Kunstleve R.W. et al. PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr. D Biol. Crystallogr.
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Recognition of the inherently unstable H2A nucleosome by Swc2 is a major determinant for unidirectional H2A.Z exchange

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By Xue Xiao, Lu Pan, Linchang Dai
| Cell Reports Verified
Highlights • Swc2-Z is a specific Swc2 region interacting with the nucleosome acidic patch • Swc2-Z facilitates the disassembly of the inherently unstable H2A nucleosome • H2A and H2A.Z residues in M4 regions affect nucleosome stability • Loss of Swc2-Z decreases SWR1 activity in vitro and in vivo Summary The multisubunit chromatin remodeler SWR1/SRCAP/p400 replaces the nucleosomal H2A-H2B dimer with the free-form H2A.Z-H2B dimer, but the mechanism governing the unidirectional H2A-to-H2A.Z...
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