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As seen in: Nature, Texas Medical Center

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Articles

Prognostic and therapeutic implications of BRAF mutations in acute myeloid leukemia

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By Darren Lee, Deedra Nicolet, Krzysztof Mrózek, Mark J Routbort, Keyur Patel, Christopher Walker, Jill Hamilton Buss, Andrew Stiff, Courtney DiNardo, Tapan M Kadia, Farhad Ravandi, Andrew Carroll Verified, Jonathan E. Kolitz, Bayard Powell, William Blum, Maria R. Baer, Guido Marcucci, Geoffrey L Uy, Wendy Stock, Richard Stone Verified, L. Jeffrey Medeiros, John Byrd, James Blachly, Robert L. Bowman, Jeffrey W. Tyner, Sanam Loghavi, Ann-Kathrin Eisfeld, Linde Miles, Yazan Abu-Shihab, Kate Plas, Andrea Laganson
| Nature Verified
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Mutation Order in Acute Myeloid Leukemia Identifies Uncommon Patterns of Evolution and Illuminates Phenotypic Heterogeneity

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By Matthew Schwede, Katharina Jahn, Jack Kuipers, Linde Miles
| Texas Medical Center
Abstract Acute myeloid leukemia (AML) has a poor prognosis and a heterogeneous mutation landscape. Although common mutations are well-studied, little research has characterized how the sequence of mutations relates to clinical features. Using published, single-cell DNA sequencing data from three institutions, we compared clonal evolution patterns in AML to patient characteristics, disease phenotype, and outcomes.
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