Lingyan Shi

Abstract Human tumours consist of highly heterogeneous and interacting cell types organized within a complex 3D space, forming a dynamic ecosystem that evolves through the development of pre-malignant lesions, tumour initiation, progression, invasion and metastasis. Understanding the operational principles of tumour evolution at a holistic 3D level is critical for improving the ability to intercept and treat cancer early.

Sometimes it’s not what you look at, it’s what you see. In clinical pathology, the ability to identify pathological changes in a biopsy sample can have an immense impact on treatment decisions and patient outcomes. Different histological stains are frequently applied to serial sections of biopsy samples to provide a multiplexed perspective and thereby increase diagnostic power while avoiding issues relating to chromatic overlap due to simultaneous stains.

Abstract Vibration of chemical bonds can serve as imaging contrast. Vibrational probes, synergized with major advances in chemical bond imaging instruments, have recently flourished and proven valuable in illuminating life processes.