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Articles by Linjun Wang
ADA2 high tumor cell-derived inosine induces an immunosuppressive microenvironment in gastric cancer by promoting macrophage M2 polarization
Abstract Metabolic alterations within the tumor microenvironment (TME) can reshape the polarization state of tumor-associated macrophages (TAMs) and weaken antitumor immunity, yet the underlying mechanisms remain unclear. In this study, we integrated multiple gastric cancer (GC) single-cell RNA sequencing (scRNA-seq) datasets and identified a tumor cell population with high adenosine deaminase 2 (ADA2) expression that is significantly associated with poor prognosis.
Study on the Flexural Damage Evolution and Failure Mechanisms of AFP-Manufactured CFRP Laminates Based on X-Ray Micro-CT
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Data will be available on request. References 1, , , et al., “Experimental Investigation of the Effect of Half Gap/Half Overlap Defects on the Strength of Composite Structures Fabricated Using Automated Fibre Placement,” Composites Part A: Applied Science and Manufacturing 150 (2021): 106610.
Spaceflight multi-omics reveals vulnerabilities of human germ cell development
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Understanding the impact of spaceflight on human reproduction is critical for interplanetary exploration, yet technical barriers have limited direct studies of germ cell biology in orbit.
Comprehensive analysis of miRNA expression, secretion profile, and functional network during myogenesis in response to spaceflight
Abstract MicroRNAs (miRNAs) are key regulators of skeletal muscle development and homeostasis. As secretory factors, previous studies have identified and validated a space flight-associated circulating microRNA (miRNA) signature in response to space flight. However, the muscle-derived miRNAs are not clear. Here, we comprehensively analyzed the variations of miRNA during mouse myoblast myogenesis in response to space flight, including expression and secretion.
A novel circSLIT2-encoded SLIT2 isoform suppresses neural invasion in gastric cancer
Abstract CircRNAs have emerged as critical regulators in various types of cancer. Neural invasion (NI) refers to a process whereby cancer cells infiltrate into the surrounding nerves and has been shown to predict poor prognosis in gastric cancer (GC). Accumulating evidence has suggested that tumor NI is a symbiotic relationship between cancer and nerves, which leads to the growth advantage for both. However, the involvement of circRNAs in the nerve-cancer cell crosstalk remains to be elucidated.
Enhancing Robustness in Prognostic Biomarker Research: A Letter on Validating Model Assumptions and Handling Zero Events
LETTER TO THE EDITOR Enhancing Robustness in Prognostic Biomarker Research: A Letter on Validating Model Assumptions and Handling Zero Events Serum Growth Differentiation Factor 15 Can Be a Novel Biomarker to Predict the Prognosis of Patients With Hepatitis C Virus Cirrhosis After Virus Elimination Yuta Myojin, Hayato Hikita, Yuki Tahata, Kenji Fukumoto, Seiya Kato, Yoichi Sasaki, Shusuke Kumazaki, Atsunori Tsuchiya, Masaru Enomoto, Daiki Miki, Hiroshi Yatsuhashi, Hidekatsu Kuroda, Yoshihito...
Planted Solutions in Quantum Chemistry: Generating Non-Trivial Hamiltonians with Known Ground States
Consistent Construction of the Density Matrix from Surface Hopping Trajectories
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Chem. Theory Comput. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Spin relaxation of electron and hole polarons in ambipolar conjugated polymers - Nature Communications
Abstract The charge-transport properties of conjugated polymers have been studied extensively for opto-electronic device applications. Some polymer semiconductors not only support the ambipolar transport of electrons and holes, but do so with comparable carrier mobilities.
The sharp structural switch of covalent cages mediated by subtle variation of directing groups - Nature Communications
Abstract It is considered a more formidable task to precisely control the self-assembled products containing purely covalent components, due to a lack of intrinsic templates such as transition metals to suppress entropy loss during self-assembly. Here, we attempt to tackle this challenge by using directing groups.
Comparison of Laparoscopic Common Bile Duct Exploration and Endoscopic Retrograde Cholangiopancreatography in the Treatment of Bile Duct Stones and Analysis of Risk Factors for Postoperative Acute Pancreatitis - PubMed
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Interpretation of adiabatic and diabatic populations from trajectories of branching corrected surface hopping†
No Access Chinese Journal of Chemical Physics 35, 488 (2022); https://doi.org/10.1063/1674-0068/cjcp2201023 The branching corrected surface hopping (BCSH) has been demonstrated as a robust approach to improve the performance of the traditional fewest switches surface hopping (FSSH) for nonadiabatic dynamics simulations of standard scattering problems [J. Chem. Phys. 150, 164101 (2019)].
Solution-processed green and blue quantum-dot light-emitting diodes with eliminated charge leakage - Nature Photonics
Abstract Quantum-dot light-emitting diodes (QD-LEDs) promise a new generation of efficient, low-cost, large-area and flexible electroluminescent devices. However, the inferior performance of green and blue QD-LEDs compared with their red counterpart is hindering the commercialization of QD-LEDs in display and solid-state lighting applications. Here we demonstrate green and blue QD-LEDs with ~100% conversion of the injected charge carriers into emissive excitons.
Reduced USP33 expression in gastric cancer decreases inhibitory effects of Slit2‐Robo1 signalling on cell migration and EMT
Abstract Objectives Gastric cancer (GC) is one of the most common cancers in the world, causing a large number of deaths every year. The Slit‐Robo signalling pathway, initially discovered for its critical role in neuronal guidance, has recently been shown to modulate tumour invasion and metastasis in several human cancers. However, the role of Slit‐Robo signalling and the molecular mechanisms underlying its role in the pathogenesis of gastric cancer remains to be elucidated.
Proper treatment of classically forbidden electronic transitions significantly improves detailed balance in surface hopping
Surface hopping is the most popular method for nonadiabatic molecular dynamics. Many have reported that it does not rigorously attain detailed balance at thermal equilibrium, but does so approximately. We show that convergence to the Boltzmann populations is significantly improved when the nuclear velocity is reversed after a classically forbidden hop.
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