Linnan Zhu

Keywords intracellular SPP1 TAMs interferon signaling TRIM21 SOCS1 immune therapy resistance Introduction T cell-targeting strategies, such as immune checkpoint blockade (ICB) therapies against CTLA4 and PD-1/PD-L1, as well as T cell receptor (TCR) or chimeric antigen receptor (CAR) T cell therapies, have revolutionized the immunotherapy landscape.1,2,3 However, only 15%–35% of patients with solid tumors benefit from these therapies, with the majority either failing to respond or rapidly...

Abstract Digitalization of the work of higher education has intensified so much that Management Information Systems (MIS) are now needed to facilitate the work of the administration and help the academic decision-making. MIS have become essential tools for administrative and academic operations in Chinese higher education institutions, yet their effective use by faculty and staff remains uneven and underexplored.

Keywords cancer-associated fibroblasts CAFs patient-derived organoid-fibroblast co-culture Perturb-seq CRISPRi CRISPRa myofibroblast activation anti-tumoral fibroblasts turning cold tumors hot immunotherapy Introduction Patients refractory to cancer immunotherapies typically feature ubiquitous fibroblasts within the tumor milieu.