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Linxiang Yin on Muck Rack

Linxiang Yin

As seen in: Nature, PLOS Biology, MDPI, Science Magazine, Cell Press
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Articles

Streptomyces produce a diphtheria toxin-like exotoxin that targets insects

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By Ying Xu, Reed M. Stubbendieck, Raghuvir Viswanatha, Lisa S. Baik, Yanhui Hu, Huan Wang, Linxiang Yin, Enzo Mameli, John Carlson, Andrew C. Doxey, Pål Stenmark, Norbert Perrimon, Cameron R. Currie, Min Dong, Anne van der Meij
| Nature Verified
Abstract Streptomyces and insects engage in complex interactions shaped by millions of years of evolution. While many beneficial relationships are well recognized, it remains unknown whether Streptomyces produce virulence factors targeting insects specifically.
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Identification and characterization of botulinum neurotoxin-like two-component toxins in Paeniclostridium ghonii

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By Zechuan Shi, Katarzyna J. Radomska, Huayong Xie, Pyung-Gang Lee, Linxiang Yin, Xin Wei, Jingyuan Shi, Geoffrey Masuyer, Travis Wentz, Pengsheng Chen, Ying Xu, Junjie Liang, Haonan Zhang, Sara Košenina, Briallen Lobb, Michael Mansfield, Sarjeet S. Gill, Sabine Pellett, Pål Stenmark
| Science Magazine Verified
Abstract Insecticidal bacterial proteins play key roles in insect-bacteria interactions and have been used as biopesticides. Here, we identify two insecticidal proteins in Paeniclostridium ghonii, designated PG-toxin 1 (PG1) and PG-toxin 2 (PG2), which are homologs of botulinum neurotoxins (BoNTs). Unlike BoNTs, PG1 and PG2 contain two separate proteins: One is the protease light chain (LC), and the other is the heavy chain containing the translocation domain and the receptor binding domain.
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Cancer Drug Delivery Systems Using Bacterial Toxin Translocation Mechanisms

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By Linxiang Yin, Hatim Thaker
| MDPI
Abstract : Recent advances in targeted cancer therapy hold great promise for both research and clinical applications and push the boundaries in finding new treatments for various currently incurable cancers. However, these therapies require specific cell-targeting mechanisms for the efficient delivery of drug cargo across the cell membrane to reach intracellular targets and avoid diffusion to unwanted tissues.
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