Lionel Mignion on Muck Rack

Lionel Mignion

As seen in: Nature, MDPI
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Articles

PPARα-mediated lipid metabolism reprogramming supports anti-EGFR therapy resistance in head and neck squamous cell carcinoma - Nature Communications

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By Hannah Zaryouh, Cedric van Marcke, Lionel Mignion, Bénédicte F. Jordan, Léo Aubert, Romain Boidot, Yvan Larondelle, Olivier Feron, Engy Vigneron, Elise Y. Lepicard, Olivier Lowyck, Manon Desgres, Guido T. Bommer
| Nature Verified
Abstract Anti-epidermal growth factor receptor (EGFR) therapy (cetuximab) shows a limited clinical benefit for patients with locally advanced or recurrent/metastatic head and neck squamous cell carcinoma (HNSCC), due to the frequent occurrence of secondary resistance mechanisms.
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Metabolic Profiling to Assess Response to Targeted and Immune Therapy in Melanoma

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By Chantale Farah, Lionel Mignion, Bénédicte F. Jordan
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer - Nature Cancer

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By Emanuele Berardi, Nicolas Joudiou, Cyril Corbet, Ramanuj DasGupta, Baki Topal, Niranjan Shirgaonkar, Lionel Mignion, Stephan J. Reshkin
| Nature Verified
Abstract Solid tumors are generally characterized by an acidic tumor microenvironment (TME) that favors cancer progression, therapy resistance and immune evasion. By single-cell RNA-sequencing analysis in individuals with pancreatic ductal adenocarcinoma (PDAC), we reveal solute carrier family 4 member 4 (SLC4A4) as the most abundant bicarbonate transporter, predominantly expressed by epithelial ductal cells.
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