Yvan Larondelle on Muck Rack

Yvan Larondelle

As seen in: Nature, MDPI, Archives of Public Health
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Articles

PPARα-mediated lipid metabolism reprogramming supports anti-EGFR therapy resistance in head and neck squamous cell carcinoma - Nature Communications

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By Hannah Zaryouh, Cedric van Marcke, Lionel Mignion, Bénédicte F. Jordan, Léo Aubert, Romain Boidot, Yvan Larondelle, Olivier Feron, Engy Vigneron, Elise Y. Lepicard, Olivier Lowyck, Manon Desgres, Guido T. Bommer
| Nature Verified
Abstract Anti-epidermal growth factor receptor (EGFR) therapy (cetuximab) shows a limited clinical benefit for patients with locally advanced or recurrent/metastatic head and neck squamous cell carcinoma (HNSCC), due to the frequent occurrence of secondary resistance mechanisms.
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Acid-exposed and hypoxic cancer cells do not overlap but are interdependent for unsaturated fatty acid resources - Nature Communications

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By Sébastien Ibanez, Ophélie Renoult, Maria Virginia Giolito, Léo Aubert, Jonas Dehairs, Johan Swinnen, Cyril Corbet, Yvan Larondelle
| Nature Verified
Abstract Cancer cells in acidic tumor regions are aggressive and a key therapeutic target, but distinguishing between acid-exposed and hypoxic cells is challenging. Here, we use carbonic anhydrase 9 (CA9) antibodies to mark acidic areas in both hypoxic and respiring tumor areas, along with an HRE-GFP reporter for hypoxia, to isolate distinct cell populations from 3D tumor spheroids. Transcriptomic analysis of CA9-positive, hypoxia-negative cells highlights enriched fatty acid desaturase activity.
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Beyond the Lab: What We Can Learn about Cancer from Wild and Domestic Animals

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By Hélène Schraverus, Yvan Larondelle, Melissa Page
| MDPI
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessReview by Hélène Schraverus , Yvan Larondelle and Melissa M. Page * Louvain Institute of Biomolecular Science and Technology (LIBST), UCLouvain, Croix du Sud 4-5/L7.07.03, B-1348 Louvain-la-Neuve, Belgium * Author to whom correspondence should be addressed.
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