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Liyong Liao on Muck Rack

Liyong Liao

As seen in: Nature, Genome Biology
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Articles

SETDB1 modulates neuroinflammation in the mouse cortex by regulating neuronal P2rx7 expression

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By Yueyan Zhu, Liyong Liao, Xixi Liu, Huan Sheng, Daijing Sun, Jiaqi Li, Qi Chen, Chenchun Zhang, Shunying Wang, YUAN ZHANG, Jie Weng, Mengling Zhou, Yuhao Dong, Wenzhu Peng, YUE LI, Yan Jiang, Jianneng Yang
| Nature Verified
Abstract Neuroinflammation is a pivotal feature of neuropsychiatric conditions, yet the brain-intrinsic epigenetic mechanisms initiating this response are not fully understood. In this study, we show that loss of the histone H3K9me3 methyltransferase SETDB1 in excitatory neurons (Setdb1-CK-cKO) triggers endogenous retrovirus (ERV) activation and neuroinflammation in the mouse cortex.
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SETDB1 regulates short interspersed nuclear elements and chromatin loop organization in mouse neural precursor cells - Genome Biology

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By Yueyan Zhu, Wenzhu Peng, Shenghui Zheng, Jie Weng, Shulong Dong, Jiaqi Li, Qi Chen, Yuhao Dong, Yun Liu, Yan Jiang, Daijing Sun, Chuanhui Ge, Liyong Liao, Weida Meng
| Genome Biology Verified
All mice were housed 5 per cage, at 21-26 ℃ under 12/12-hour day/night cycle, and were allowed sterile food and water ad libitum. Generation of knockout mice and neurosphere culture of neural precursor cells (NPCs) were conducted according to established protocol [18]. In brief, female Setdb12lox/2lox mice were crossed with male Setdb12lox/+, Nestin-Cre mice and checked for vaginal plug.
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