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Shunying Wang on Muck Rack

Shunying Wang

As seen in: Nature
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Articles

SETDB1 modulates neuroinflammation in the mouse cortex by regulating neuronal P2rx7 expression

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By Yueyan Zhu, Liyong Liao, Xixi Liu, Huan Sheng, Daijing Sun, Jiaqi Li, Qi Chen, Chenchun Zhang, Shunying Wang, YUAN ZHANG, Jie Weng, Mengling Zhou, Yuhao Dong, Wenzhu Peng, YUE LI, Yan Jiang, Jianneng Yang
| Nature Verified
Abstract Neuroinflammation is a pivotal feature of neuropsychiatric conditions, yet the brain-intrinsic epigenetic mechanisms initiating this response are not fully understood. In this study, we show that loss of the histone H3K9me3 methyltransferase SETDB1 in excitatory neurons (Setdb1-CK-cKO) triggers endogenous retrovirus (ERV) activation and neuroinflammation in the mouse cortex.
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Knockdown of ELF4 aggravates renal injury in ischemia/reperfusion mice through promotion of pyroptosis, inflammation, oxidative stress, and endoplasmic reticulum stress - PubMed

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By Wenming Wang, Shunying Wang
| ncbi.nlm.nih.gov
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