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long non-coding RNAs

As seen in: Wiley Online Library, ScienceDirect, Cell Metabolism
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Articles

LncRNA‐GPHN Regulates Epilepsy by Inhibiting Apoptosis via the miR‐320/YWHAH Axis in an Immature Rat Model of Status Epilepticus

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By long non-coding RNAs, jun chen, Related Diseases, Xueyi Rao
| Wiley Online Library Verified
1 Introduction Epilepsy is a chronic neurological disorder characterised by recurrent seizures due to abnormal electrical discharges in the brain. Approximately 50 million people worldwide suffer from epilepsy, making it one of the most common serious neurological diseases [1]. Epilepsy not only imposes physical and psychological burdens on patients but also significantly impacts society and healthcare systems [2].
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Role of long noncoding RNAs in the regulation of alternative splicing in glioblastoma

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By long non-coding RNAs, Sadat Dokanehiifard, Manfred Hauben, Bahram M. Soltani
| ScienceDirect Verified
Section snippets GBM Brain tumors, with their high morbidity and mortality, face treatment challenges due to the blood–brain barrier, sensitive brain locations, and unique biological features.
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LncRNA SOX21-AS1 Promotes Activation of BV2 Cells via Epigenetical Silencing of SOCS3 and Aggravates Parkinson’s Disease

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By long non-coding RNAs
| karger.com
Background: LncRNAs perform a crucial impact on microglia’s activation in Parkinson’s disease (PD). Here, our purpose was to probe the function and involved mechanism of lncRNA SOX21-AS1 on microglial activation in PD. Methods: Mice were treated with MPTP, and BV2 cells were treated with LPS/ATP to build PD animal and cell models. Genes’ expression was measured using RT-qPCR, immunoblotting, and IHC stain. ELISA was applied for testing inflammatory factors’ levels.
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