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Louma G. Laboratory on Muck Rack

Louma G. Laboratory

As seen in: Cell Reports
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Articles

SMYD5 is a regulator of the mild hypothermia response

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By Salvor Rafnsdottir, Kijin Jang, Sara Tholl Halldorsdottir, Louma G. Laboratory
| Cell Reports Verified
Highlights • SMYD5 represses the neuroprotective gene SP1 at 37°C by depositing H3K36me3 • Mild hypothermia reduces SMYD5 levels both in vitro and in vivo • Reduction in SMYD5 levels during hypothermia occurs via proteasomal degradation • SMYD5 similarly regulates 37 other genes indicating a broader role in the response Summary The mild hypothermia response (MHR) maintains organismal homeostasis during cold exposure and is thought to be critical for the neuroprotection documented with...
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