Lu Long
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Articles by Lu Long
Integrated analysis of insulin resistance reveals metabolic remodeling following diet switch–triggered calorie reduction
Abstract Insulin resistance (IR) links obesity to metabolic disorders. While weight loss reverses IR, we show that calorie reduction (CR) can do so in obese mice within a day before significant weight loss. In contrast to whole-body IR, individual tissues do not revert to their original chow diet–fed states after CR.
TurboID‐Based Proximity Labelling Identifies MED25 as an Activator of GoPGF‐Mediated Gland Formation and Gossypol Biosynthesis in Cotton
Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description pce70026-sup-0001-Revised_sup_figs1_11_202506.docx2.7 MB Revised sup figs1–11 202506. pce70026-sup-0002-Revised_table_S1_6.xlsx318 KB Revised table S1–6. References , , , and . 1966. “Bahtim 110, a New Strain of Egyptian Cotton Free From Gossypol.” Empire Cotton Growing Review 43: 112–120. , , , et al. 2020.
Effects of Different Biochars on Physicochemical Properties and Microbial Communities in Tea Plantation Soils
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Breeding triple‐advantage cottonseed with higher yield, enhanced nutrition, and reduced toxicity by redirecting terpenoid metabolism to astaxanthin
Introduction Cotton fibre is an essential commodity in daily life and is often referred to as ‘white gold’. In addition to its fibre, cottonseed is a valuable byproduct, rich in unsaturated fatty acids, proteins, and essential minerals, making it highly nutritious and economically significant (Alford et al., 1996; Kumar et al., 2023; Yang et al., 2017).
A Luminescent Proton Conductor Based on Dy2 SMM
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Association of depression with severe non-alcoholic fatty liver disease: evidence from the UK Biobank study and Mendelian randomization analysis - Scientific Reports
Abstract The relationship between depression and severe non-alcoholic fatty liver disease (NAFLD) has not been clearly defined. We conducted a longitudinal cohort study and a two-sample Mendelian randomization (MR) analysis to assess the association of depression with severe NAFLD risk. We used individual data from the UK Biobank study with 481,181 participants, and summary data from published genome-wide association studies.
Association between Pan‐Immune Inflammation Value and Sarcopenia in Hypertensive Patients, NHANES 1999-2018
1 Introduction Hypertension is one of the most prevalent chronic diseases globally and the leading cause of death and disability from cardiovascular disease (CVD) [1]. Approximately 9.4 million people die from hypertension annually, accounting for 45% of deaths from ischemic heart disease and 51% of deaths from cerebrovascular disease [2, 3].
GhHAM regulates GoPGF‐dependent gland development and contributes to broad‐spectrum pest resistance in cotton
CONFLICT OF INTEREST The authors declare that there is no conflict of interest. Supporting Information Filename Description tpj16803-sup-0001-FigureS1-S11.docxWord 2007 document , 3.9 MB Figure S1. Sequence alignment of the Gohir.A08G172200 and Gohir.D08G190500 coding regions. Figure S2. Sequence alignment of the Gohir.A08G172200 and Gohir.D08G190500 protein sequences. Figure S3. Conserved domain analysis of GhHAM. Figure S4. Phylogenetic analysis of GhHAM and its homologs in G. hirsutum. Figure S5.
Inhibition of phosphodiesterase 4 attenuates aquaporin 4 expression and astrocyte swelling following cerebral ischemia/reperfusion injury
Supporting Information Filename Description glia24572-sup-0001-Supinfo.docWord document, 1.4 MB Data S1: Supplementary Information. REFERENCES , , , , , , , , , , & (2003). An alpha-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain. Proceedings of the National Academy of Sciences of the United States of America, 100, 2106–2111. , , , , , , , , & (2021).
Agronomy | Free Full-Text | Effects of the Combined Application of Nitrogen and Selenium on Tea Quality and the Expression of Genes Involved in Nitrogen Uptake and Utilization in Tea Cultivar ‘Chuancha No.2’
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Polyethyleneimine-coated MXene quantum dots improve cotton tolerance to Verticillium dahliae by maintaining ROS homeostasis - Nature Communications
Abstract Verticillium dahliae is a soil-borne hemibiotrophic fungal pathogen that threatens cotton production worldwide. In this study, we assemble the genomes of two V. dahliae isolates: the more virulence and defoliating isolate V991 and nondefoliating isolate 1cd3-2.
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Alcohol use disorder (AUD) results in numerous disabilities and approximately 3 million deaths annually, caused mainly by alcoholic liver disease (ALD). Phosphodiesterase IV (PDE4) has emerged as an attractive molecular target for a new treatment for AUD and ALD. In this study, we describe the identification of 5-azaindazole analogues as PDE4 inhibitors against AUD and ALD.
The dual role of GoPGF reveals that the pigment glands are synthetic sites of gossypol in aerial parts of cotton
Fig. S1 Expression profile of GoPGF in different tissues of gland cotton. Fig. S3 KEGG classification of the identified top eight enriched groups of the downregulated genes in gland cells compared with those in nongland cells. Fig. S4 Chromatin binding profiles of GoPGF in the 2000 bp promoter region upstream of the transcription start site of 12 gossypol biosynthetic genes. Fig. S5 Yeast one-hybrid assays showing the GoPGF binding ability to the CYP706B1, DH1, CYP82D113, SPG and 2-ODD-1 promoters. Fig.
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