Luca Zinzula

Abstract Marburg virus (MARV) causes lethal hemorrhagic fever in humans, posing a threat to global health. We determined by cryogenic electron microscopy (cryo-EM) the MARV helical ribonucleoprotein (RNP) complex structure in single-layered conformation, which differs from the previously reported structure of a double-layered helix.

1 INTRODUCTION Brucella ceti and Brucella pinnipedialis are Gram-negative bacteria known to infect cetacean and pinniped populations, respectively, and to cause brucellosis—a severe chronic disease—with major clinical signs such as meningoencephalitis, discospondylitis, sub-cutaneous abscesses, endometritis, and myocarditis, often resulting in affected animals stranding ashore and in fatal outcome (Foster et al., 2007; Guzmán-Verri et al., 2012; Nymo et al., 2011).

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