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Lucas Sullivan

Columbus, San Francisco
As seen in: MSN, Nature, USA Today, Yahoo News, Business Wire, The Toronto Star, Xbox Wire, Bleacher Report, GamesRadar+, PC Gamer and
Realtor with Re/Max Impact. Lover of Central Ohio. Working in the community to make it better. Go Browns!!
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Articles

Loss of the USP22 deubiquitylase confers resistance to chemotherapy in small cell lung cancer

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By Scott G. Best, Daniel Hippe, Eli Grunblatt, Jackson P. Fatherree, Pritha Chanana, Feinan Wu, Richard Ivey, Jacob Kennedy, David Sokolov, Ali Ibrahim, Haodong Xu, Raymond J. Jr., Lucas Sullivan, Patrick J Paddison, Amanda G. Paulovich, David Macpherson
| Nature Verified
Abstract Small cell lung cancer (SCLC) responds exceptionally well to cytotoxic chemotherapy. However, relapse with the emergence of chemoresistant disease is rapid and accompanied by poor treatment outcomes. To understand the genetic basis of chemoresistance in SCLC, we apply in vivo CRISPR deletion screening to patient-derived xenograft (PDX) models. Top screen hits include genes encoding components of the transcriptional co-activator SAGA (Spt-Ada-Gcn5 acetyltransferase) complex.
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Mitochondria produce lactate to vent redox pressure

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By Serwah Danquah, Lucas Sullivan
| Cell Press Verified
Get full text access Log in, subscribe or purchase for full access. References 1. Cori, C.F. ∙ Cori, G.T. Glycogen formation in the liver from d- and l-lactic acid J. Biol. Chem. 1929; 81:389-403 2. Hui, S. ... Glucose feeds the TCA cycle via circulating lactate Nature. 2017; 551:115-118 3. Glancy, B. ... Mitochondrial lactate metabolism: history and implications for exercise and disease J. Physiol. 2021; 599:863-888 4. Brooks, G.A. The science and translation of lactate shuttle theory Cell Metab.
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Succinate dehydrogenase loss suppresses pyrimidine biosynthesis via succinate-mediated inhibition of aspartate transcarbamylase

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By Madeleine L. Hart, David Sokolov, Serwah Danquah, Eric Zheng, Alex Doan, Kristian Davidsen, David Macpherson, Lucas Sullivan
| Nature Verified
Abstract Decreased availability of the amino acid aspartate constrains cell function across diverse biological contexts, but the temporal interplay between aspartate abundance, downstream metabolic changes and functional effects remains poorly understood. Here we show that succinate dehydrogenase (SDH) inhibition suppresses pyrimidine synthesis via dual effects of cellular aspartate depletion and succinate accumulation.
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