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Lucia-Maria Kaps on Muck Rack

Lucia-Maria Kaps

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Lysine-11 ubiquitination drives type-I/III interferon induction by cGAS–STING and Toll-like receptors 3 and 4 - Nature Cell Biology

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By Ana Beatriz Varanda, Maykel Arias, Iratxe Uranga-Murillo, Long Châu, Johannes Brägelmann, Diego De Miguel, Kerstin Becker, Rocío Martín, Antonio Alcamí, Brian Ferguson, Julian Pardo, Eva Rieser, Henning Walczak, Alexis Betrancourt, M. Talha Cinko, Natacha Peña, Lucia-Maria Kaps, Bianca Buratti, Ramona Casper
| Nature Verified
Abstract Pattern recognition receptor (PRR)-induced interferon (IFN) is critical for effective immunity. The PRRs Toll-like receptor (TLR) 3, TLR4 and cyclic GMP–AMP synthase (cGAS), together with the stimulator of IFN genes (STING), signal through TANK-binding kinase 1 (TBK1), which activates the type-I/III IFN-inducing transcription factor interferon-response factor 3 (IRF3). The mechanism by which these PRRs activate TBK1 remains unresolved.
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