Brian Ferguson on Muck Rack

Brian Ferguson

As seen in: CBS Sports, Nature, Wiley Online Library, PLOS ONE, Frontiers, The Globe and Mail, Hot Rod Magazine, Charleston Gazette-Mail, The Journal of Immunology
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Articles

Lysine-11 ubiquitination drives type-I/III interferon induction by cGAS–STING and Toll-like receptors 3 and 4 - Nature Cell Biology

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By Ana Beatriz Varanda, Maykel Arias, Iratxe Uranga-Murillo, Long Châu, Johannes Brägelmann, Diego De Miguel, Kerstin Becker, Rocío Martín, Antonio Alcamí, Brian Ferguson, Julian Pardo, Eva Rieser, Henning Walczak, Alexis Betrancourt, M. Talha Cinko, Natacha Peña, Lucia-Maria Kaps, Bianca Buratti, Ramona Casper
| Nature
Abstract Pattern recognition receptor (PRR)-induced interferon (IFN) is critical for effective immunity. The PRRs Toll-like receptor (TLR) 3, TLR4 and cyclic GMP–AMP synthase (cGAS), together with the stimulator of IFN genes (STING), signal through TANK-binding kinase 1 (TBK1), which activates the type-I/III IFN-inducing transcription factor interferon-response factor 3 (IRF3). The mechanism by which these PRRs activate TBK1 remains unresolved.
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Time of urine sampling may influence the association between urine specific gravity and body composition

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By Patrick Wilson, Brian Ferguson, Ian Winter
| PLOS ONE
Loading metrics Open Access Peer-reviewed Research Article Citation: Wilson PB, Ferguson BK, Winter IP (2025) Time of urine sampling may influence the association between urine specific gravity and body composition. PLoS One 20(9): e0333479. https://doi.org/10.1371/journal.pone.0333479 Editor: Jeremy P. Loenneke, University of Mississippi, UNITED STATES OF AMERICA Received: June 4, 2025; Accepted: September 12, 2025; Published: September 26, 2025 Copyright: © 2025 Wilson et al.
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Molecular basis of autoimmune disease protection by MDA5 variants

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By Rahul Singh, Joe D Joiner, Brian Ferguson, Marleen Zwaagstra
| biorxiv.org
Abstract MDA5 recognizes dsRNA from viruses and retroelements. Cooperative filament formation and ATP-dependent proofreading confer MDA5 with the necessary sensitivity and specificity for dsRNA. The gene encoding MDA5 is a hotspot for disease-associated variants. Many MDA5 variants are associated with protection from autoimmune disease, while increasing the risk of infection and chronic inflammation, but how these variants affect MDA5-dependent RNA sensing remains unclear.
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