Lucia Yi Du

Editor’s summary Inborn errors of immunity (IEI) to Mycobacterium tuberculosis (M.tb) infection can underlie tuberculosis. Ogishi et al. identified a rare autosomal recessive complete deficiency in the lymphocytic surface receptor LY9 that was a previously unknown IEI in three unrelated individuals with tuberculosis. This LY9 deficiency was linked to impaired IFN-γ production by CCR4−CCR6+CXCR3+T-bet+RORγT+ TH1* memory cells.

Editor’s summary Host responses to bacterial infection are influenced by circadian rhythms. Neutrophils play a key role in antibacterial immunity, yet how the neutrophil circadian clock is regulated is not well understood. Using a zebrafish model of bacterial infection, Du et al. identified that the core clock component Per2 was elevated in neutrophils under constant light conditions and was required for bactericidal function and host survival.

Editor’s summary The ability to precisely modulate T cell signaling with modified proteins can greatly enhance T cell survival and function. Zheng et al. used this approach to engineer an optimized form of herpesvirus saimiri tyrosine kinase interacting protein (TIP) to recruit the LCK kinase to different signal transducer and activator of transcription (STAT) proteins.