Pramuk Keerthisinghe

Editor’s summary Host responses to bacterial infection are influenced by circadian rhythms. Neutrophils play a key role in antibacterial immunity, yet how the neutrophil circadian clock is regulated is not well understood. Using a zebrafish model of bacterial infection, Du et al. identified that the core clock component Per2 was elevated in neutrophils under constant light conditions and was required for bactericidal function and host survival.

Research Article IMMUNE REGULATION INTRODUCTION The circadian clock is a 2.5-billion-year-old cellular timekeeper that coordinates the activity of an organism in preparation for recurring daily environmental challenges (1). Host responses to bacterial infection demonstrate strong circadian rhythmicity, with peak immune responses often observed during an animal’s early active phase (2–4).

Abstract Gluten, which is found in cereals such as wheat, rye and barley, makes up a major dietary component in most western nations, and has been shown to promote body mass gain and peripheral inflammation in mice. In the current study, we investigated the impact of gluten on central inflammation that is typically associated with diet-induced obesity.