Luipa Khandker on Muck Rack

Luipa Khandker

As seen in: Cell Reports
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By Luipa Khandker, Marisa A. Jeffries, Yun-Juan Chang, Marie L. Mather, Jennifer Bourne, Isis Ornelas, Wendy B. Macklin, Teresa Wood, Angelina V. Evangelou, Azadeh K. Tafreshi, Ozlem Bozdagi-Gunal
| Cell Reports Verified
Highlights • scRNA sequencing shows distinct oligodendrocyte precursors in brain and spinal cord • Brain and spinal cord oligodendroglia differentially regulate cholesterol synthesis • mTOR is necessary for normal cholesterol biosynthesis in oligodendroglia • mTOR is necessary for myelin maintenance Summary Brain and spinal cord oligodendroglia have distinct functional characteristics, and cell-autonomous loss of individual genes can result in different regional phenotypes.
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