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Luis Barreiro

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Articles

Widespread gene-environment interactions shape the immune response to SARS-CoV-2 infection in hospitalized COVID-19 patients

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By Haley E. Randolph, Raul Aguirre-Gamboa, Elsa Brunet-Ratnasingham, Tomoko Nakanishi, Zepeng Mu, Veronica Locher, Catherine Larochelle, Alexandre Prat, Nathalie Arbour, Anne Dumaine, Andrés Finzi, Madeleine Durand, J. Brent Richards, Daniel Kaufmann, Luis Barreiro, Ellen Ketter, Cary Brandolino
| Nature Verified
Abstract Genome-wide association studies performed in COVID-19 patients have uncovered various loci significantly associated with susceptibility to SARS-CoV-2 infection and disease severity. However, the underlying cis-regulatory genetic factors contributing to heterogeneity in the response to SARS-CoV-2 infection and their impact on clinical phenotypes remain enigmatic.
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