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Nathalie Arbour

As seen in: Nature, Journal of Virology
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Articles

Widespread gene-environment interactions shape the immune response to SARS-CoV-2 infection in hospitalized COVID-19 patients

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By Haley E. Randolph, Raul Aguirre-Gamboa, Elsa Brunet-Ratnasingham, Tomoko Nakanishi, Zepeng Mu, Veronica Locher, Catherine Larochelle, Alexandre Prat, Nathalie Arbour, Anne Dumaine, Andrés Finzi, Madeleine Durand, J. Brent Richards, Daniel Kaufmann, Luis Barreiro, Ellen Ketter, Cary Brandolino
| Nature Verified
Abstract Genome-wide association studies performed in COVID-19 patients have uncovered various loci significantly associated with susceptibility to SARS-CoV-2 infection and disease severity. However, the underlying cis-regulatory genetic factors contributing to heterogeneity in the response to SARS-CoV-2 infection and their impact on clinical phenotypes remain enigmatic.
Open in Who Shared Issue with article?

Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity - Nature Communications

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By Haley E. Randolph, Justin Bélair, Michael Hultström, Julia Niessl, Nathalie Brassard, Gérémy Sannier, Amanda Marks, Hugo Zeberg, Miklos Lipcsey, Robert Frithiof, Anders O. Larsson, Sirui Zhou, Tomoko Nakanishi, David Morrison, Dani Vézina, Catherine Larochelle, Alexandre Prat, Janet Cunningham, Nathalie Arbour, J. Brent Richards, Nicolas Chomont, Luis B. Barreiro, Guy Wolf
| Nature Verified
Abstract Plasma RNAemia, delayed antibody responses and inflammation predict COVID-19 outcomes, but the mechanisms underlying these immunovirological patterns are poorly understood. We profile 782 longitudinal plasma samples from 318 hospitalized patients with COVID-19.
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Neuroinvasion by Human Respiratory Coronaviruses

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By Robert Day, Nathalie Arbour, Pierre J. Talbot
| Journal of Virology Verified
Pathogenesis and Immunity Nathalie Arbour, Robert Day, Jia Newcombe, Pierre J. Talbot DOI: 10.1128/JVI.74.19.8913-8921.2000 ABSTRACT Human coronaviruses (HCoV) cause common colds but can also infect neural cell cultures. To provide definitive experimental evidence for the neurotropism and neuroinvasion of HCoV and its possible association with multiple sclerosis (MS), we have performed an extensive search and characterization of HCoV RNA in a large panel of human brain autopsy samples.
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