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Articles by Luise Graichen
No detectable association of APOE ε4 with spatial navigation and broader cognition in healthy young adults
Abstract Alzheimer’s disease (AD) causes progressive memory loss and disorientation. It is preceded by a prolonged preclinical phase marked by pathological changes in medial temporal lobe regions involved in spatial navigation. Spatial navigation tasks have been proposed for early AD detection, and altered navigation performance was reported in older carriers of the apolipoprotein E (APOE) ε4 allele, the major genetic risk factor for sporadic AD.
Entorhinal grid-like codes for visual space during memory formation
Abstract Eye movements, such as saccades, allow us to gather information about the environment and, in this way, can shape memory. In non-human primates, saccades are associated with the activity of grid cells in the entorhinal cortex. Grid cells are essential for spatial navigation, but whether saccade-based grid-like signals play a role in human memory formation is currently unclear.
Functional analysis of polymorphisms at the S1/S2 site of SARS-CoV-2 spike protein
Loading metrics Open Access Peer-reviewed Research Article Prerna Arora, Anzhalika Sidarovich, Luise Graichen, Bojan Hörnich, Alexander Hahn, Markus Hoffmann , Stefan Pöhlmann Prerna Arora, Anzhalika Sidarovich, Luise Graichen, Bojan Hörnich, Alexander Hahn, Markus Hoffmann, Stefan Pöhlmann Published: March 25, 2022 https://doi.org/10.1371/journal.pone.0265453 Abstract Several SARS-CoV-2 variants emerged that harbor mutations in the surface unit of the viral spike (S) protein that enhance...
SARS-CoV-2 mutations acquired in mink reduce antibody-mediated neutralization
Highlights - SARS-CoV-2 from mink harbor up to five mutations in the spike protein - Entry inhibitors under clinical evaluation block mink spike proteins - Mutation Y453F confers partial escape from a therapeutic antibody - Y453F allows evasion of antibodies induced by SARS-CoV-2 infection of humans Summary Transmission of SARS-CoV-2 from humans to farmed mink was observed in Europe and the US.
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