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Luke Barron on Muck Rack

Luke Barron

As seen in: The Journal of Biological Chemistry
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Articles

T Cells Encountering Myeloid Cells Programmed for Amino Acid-dependent Immunosuppression Use Rictor/mTORC2 Protein for Proliferative Checkpoint Decisions

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By Chitra Subramanian, Luke Barron, Joseph E. Qualls, Geoffrey Neale
| The Journal of Biological Chemistry Verified
Modulation of T cell proliferation and function by immunoregulatory myeloid cells are an essential means of preventing self-reactivity and restoring tissue homeostasis. Consumption of amino acids such as arginine and tryptophan by immunoregulatory macrophages is one pathway that suppresses local T cell proliferation.
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T cells encountering myeloid cells programmed for amino acid-dependent immunosuppression use Rictor/mTORC2 for proliferative checkpoint decisions

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By Chitra Subramanian, Joseph E. Qualls, Geoffrey Neale, Luke Barron
| The Journal of Biological Chemistry Verified
Author contributions: LV and AS did the majority of the experiments. CS and CR did the arginine metabolic labeling experiments. LB and TW did schistosome experiments and contributed to the design of the in vitro culture system. GN performed all bioinformatic analyses. JQ, AA and SJ did additional experiments. LV, JQ, CR, TW and PM wrote and edited the manuscript. TW and PM conceived the overall study design.
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