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Luke C. Bartelt on Muck Rack

Luke C. Bartelt

As seen in: Science Magazine, BioRxiv, Cell Reports
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Articles

Dysregulation of zebrin-II cell subtypes in the cerebellum is a shared feature across polyglutamine ataxia mouse models and patients

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By Jingjing Ding, Victor Fattori, Rebecca Wallings, Luke C. Bartelt
| Science Magazine Verified
Editor’s summary Spinocerebellar ataxias (SCAs) are neurodegenerative diseases affecting coordination and movement. Purkinje cells (PCs) are especially vulnerable in SCAs, but their low abundance makes cell type–specific transcriptomic profiling difficult. Using a PC enrichment protocol for snRNA-seq, Bartelt et al. discovered that genes contributing to zebrin-II PC subtype identity were dysregulated in the SCA7-266Q mouse model.
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Purkinje-Enriched snRNA-seq in SCA7 Cerebellum Reveals Zebrin Identity Loss as a Central Feature of Polyglutamine Ataxias

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By Luke C. Bartelt, Pawel M. Switonski, Juliana Carvalho, Grazyna Adamek
| BioRxiv
Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.
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Purkinje-Enriched snRNA-seq in SCA7 Cerebellum Reveals Zebrin Identity Loss as a Central Feature of Polyglutamine Ataxias

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By Luke C. Bartelt, Pawel M. Switonski, Juliana Carvalho, Lisa Duvick
| BioRxiv
Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.
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