Articles by Luke Gilbert
Predicting cellular responses to perturbation across diverse contexts with State
Keywords machine learning artificial intelligence transcriptomics single-cell RNA sequencing cell biology perturbation gene expression gene regulation systems biology Introduction Accurately predicting the impact of cellular perturbations at scale has the potential to reshape targeted therapies.
A Violent Game | Yale Daily News
This piece won an honorable mention in the nonfiction category of the 2026 Wallace Prize. The modest things I know about greyhound racing, I know because of my dog Strozzi. When my parents adopted him I was nineteen, and months earlier I had left home in Charlotte for college, in Connecticut.
The Meaning Behind The Song: Night Ride Home by Joni Mitchell
The Meaning Behind The Song: Night Ride Home by Joni Mitchell Joni Mitchell, one of the most renowned and influential singer-songwriters of our time, has left an indelible mark on the world of music. Among her remarkable creations, Night Ride Home is a song that stands out for its unique blend of melody and lyrics. Released in 1991, this hauntingly beautiful song has inspired countless fans around the world. In this article, we explore the meaning behind the song Night Ride Home by Joni Mitchell.
The Meaning Behind The Song: Baby Please Don't Go by Them
The Meaning Behind The Song: Baby Please Don’t Go by Them Baby Please Don’t Go, written and originally performed by blues musician Big Joe Williams in 1935, quickly became a staple in the blues genre. However, it was the rendition by the Northern Irish rock band Them, led by the iconic Van Morrison, that truly solidified the song’s place in music history. Released in 1964, Them’s version of Baby Please Don’t Go showcased their raw energy and captured the attention of audiences worldwide.
Environmental challenge rewires functional connections among human genes
New Results doi: https://doi.org/10.1101/2023.08.09.552346 Abstract A fundamental question in biology is how a limited number of genes combinatorially govern cellular responses to environmental changes. While the prevailing hypothesis is that relationships between genes, processes, and ontologies could be plastic to achieve this adaptability, quantitatively comparing human gene functional connections between specific environmental conditions at scale is very challenging.
Effects of a games-based physical education lesson on cognitive function in adolescents
Introduction Chief Medical Officer guidance states that young people aged 5–18 years should participate in an average of 60 min per day moderate-to-vigorous physical activity (MVPA) to enhance health and well-being (UK Chief Medical Officers, 2019); yet recent data suggest that only 44.6% of children and adolescents in England achieve these recommendations (Sport England, 2021).
IBD 3 Weight-based prescribing of thiopurines may not accurately optimise metabolite levels in the safe and therapeutic range: a paediatric IBD study
IBD 3 Weight-based prescribing of thiopurines may not accurately optimise metabolite levels in the safe and therapeutic range: a paediatric IBD study Farah M Barakat, Sophie Lewis, James Ashton, Luke Gilbert, Kouros Driscoll, Claire Barnes, Adebola Sholeye-Bolaji, Hang Phan, Guo Cheng, Rachel Haggarty, Akshay Batra, Nadeem A Afzal, R Mark Beattie, Sarah Ennis, Tracy Coelho University Hospital of Southampton Abstract Background Thiopurine drugs have been widely used in the treatment of IBD for...
CRISPR without the cut: CRISPRa/i for modulating gene expression
2 Mar 2022 12:00 PM ET Register NOWRemaining time: Charles Gersbach, Ph.D.Speaker Luke Gilbert, Ph.D.Speaker Jackie Oberst, Ph.D.Moderator This webinar is brought to you by the Science/AAAS Custom Publishing Office. The most widely used application of CRISPR-Cas9 is to target a gene of interest and generate a double-strand break (DSB) at the target site.
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